|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and 93 with Myasthenia Gravis (MG) and 282 unrelated controls.
|
26605347 |
2015 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
RA susceptibility is linked to specific HLA alleles belonging to DRB1 04 locus, such as DRB1 0401, while Cw 0602 and DRB1 07 predispose to PsA.
|
23298497 |
2013 |
|
HLA-DRB1
|
0.090 |
Biomarker
|
disease |
BEFREE |
HLA-Cw*06 and HLA-DRB1*07 are associated with patients with PsA having type I psoriasis, suggesting that the primary association is with age of onset of psoriasis.
|
17728335 |
2008 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Patients with PsA carrying both HLA-Cw6 and HLA-DRB1*07 alleles have a less severe course of arthritis.
|
17223660 |
2007 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The presence of anti-CCP antibodies in PsA was significantly associated with the HLA-DRB1 shared epitope (P<0.005), erosive disease (P<0.05), number of swollen joints (P<0.02) and DMARD use (P<0.05).
|
15901902 |
2005 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
One hundred fifty-eight patients with well documented PsA and 250 controls were typed for HLA-DRB1 alleles including the SE by polymerase chain reaction.
|
12508396 |
2003 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
TNFA and DRB I alleles were not significantly associated with PsA.
|
12022360 |
2002 |
|
HLA-DRB1
|
0.090 |
Biomarker
|
disease |
BEFREE |
Some findings can be concluded from the study: (1) the frequency of HLA-B*5701, B*3801, B*39, B*27, Cw*0602, Cw*07, DRB1*0402, and DRB1*0701 were not found to be significantly increased in PsA; (2) no significant differences of TNFalpha promoter alleles at positions -308 and -238 were found between PsA and healthy controls; (3) the trinucleotide repeat polymorphism MICA-A9 was present at a higher frequency in PsA patients, (p(c) < 0.009, RR = 3.34, EF = 0.39); and (4) MICA-A9 polymorphism was found in linkage disequilibrium with HLA-B alleles (B*5701, B*3801) described to be associated with PsA in Caucasians.
|
11390038 |
2001 |
|
HLA-DRB1
|
0.090 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0402 was higher among patients with PsA.
|
11704286 |
2001 |