Gene: CCR6 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease BEFREE <b>Objectives:</b> To analyze occurrence and plasticity of two recently described distinct subtypes of Th1 cells named classic (CD161-/CCR6-) and non-classic (CD161+/CCR6+) Th1 cells in early rheumatoid arthritis (RA) patients and healthy controls (HCs). 31512538 2019
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease BEFREE CCR6 has been associated with RA in genome-wide association studies and has been shown to be an interesting candidate for a therapeutic approach, considering its and CCL20's expression patterns within the tissue as well as the immune system. 24394994 2014
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease BEFREE CCR6 or its chemokine ligand CCL20 might represent a possible new target for the treatment of RA. 30133119 2018
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease BEFREE CCR6+ ILC3s may play some roles in the development of RA through the production of IL-17 and IL-22. 31470891 2019
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASDB A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. 20453841 2010
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease CTD_human A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. 20453841 2010
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASCAT A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. 20453841 2010
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 AlteredExpression disease BEFREE CCL17, CCL20, and CCL28, which are chemokine ligands of CCR4, CCR6, and CCR10, respectively, were abundantly expressed in RA synovial tissue compared to OA. 30619268 2018
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease BEFREE Direct sequencing of DNA was performed to ascertain whether the functional dinucleotide polymorphism of CCR6 previously identified in RA (CCR6DNP) was also present in SSc. 23983073 2013
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease BEFREE Evidence of epistatic interaction between DPP4 and CCR6 in patients with rheumatoid arthritis. 27587881 2016
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 AlteredExpression disease BEFREE Furthermore, expression of CCR6 was found in infiltrating mononuclear cells in the cellular clusters and around the vessels of RA synovial tissue. 11472439 2001
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114 2019
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASDB Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842 2010
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease CTD_human Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842 2010
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASCAT Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842 2010
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease CTD_human High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASCAT High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. 24532676 2015
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease LHGDN Immunohistochemical analysis for CCR6, CCL20, and RANKL was performed on bone samples from RA patients. 17133360 2007
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease GWASDB Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. 22446963 2012
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 GeneticVariation disease BEFREE Moreover proteins encoded by established genetic risk factors for RA including CCR6, CD226, CSF2, EOMES, ETS1, GATA3, IL2, IL6R, IL23R, IKZF3, IRAK1, IRF4, IRF8, PRKCQ, PRDM1, RBPJ, RUNX1 and TAGAP are directly involved in Th17 cell differentiation and/or function. 29254845 2018
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.500 Biomarker disease BEFREE Moreover, current approaches to target CCR6+ Th cells and future directions of research to find specific CCR6+ Th cell targets in the treatment of patients with RA and other CCR6+ Th cell mediated autoimmune diseases are highlighted. 25828206 2015