Gene: IL6R ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease BEFREE Tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, has recently been approved as a biological therapy for rheumatoid arthritis (RA) and other diseases. 22467923 2012
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 GeneticVariation disease GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease BEFREE This pattern of effects was consistent with IL6R blockade from infusions of tocilizumab (4-8 mg/kg every 4 weeks) in patients with rheumatoid arthritis studied in randomised trials. 22421340 2012
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease CTD_human High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Therapeutic disease CTD_human High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease BEFREE Tocilizumab, a monoclonal antibody to interleukin-6 receptor, was recently approved for the treatment of moderate-to-severe rheumatoid arthritis. 21412181 2011
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 GeneticVariation disease BEFREE Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity. 20661738 2011
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 GeneticVariation disease BEFREE In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA. 21981268 2011
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease BEFREE To investigate the possible role of a functional polymorphism in the soluble interleukin 6 receptor (sIL-6R) gene in the genetic background of rheumatoid arthritis (RA). 19713205 2010
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 GeneticVariation disease BEFREE The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity. 20551110 2010
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Therapeutic disease CTD_human Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. 16729287 2006
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease CTD_human Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. 16729287 2006
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease BEFREE Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. 12794819 2003
Entrez Id: 3570
Gene Symbol: IL6R
IL6R 		0.500 Biomarker disease BEFREE Soluble interleukin-6 receptor in plasma and in lymphocyte culture supernatants of healthy individuals and patients with systemic lupus erythematosus and rheumatoid arthritis. 11208277 2001