The C allele frequencies of pre-mir-152rs1707 (C vs. T, OR = 6.671, 95% CI: 3.146-14.147) was also significantly associated with an increased risk of asthma in a Chinese Han population (p < 0.001).
These combined results are consistent with +3142 allele-specific targeting of HLA-G by the miR-152 family and support our hypothesis that miRNA regulation of sHLA-G in the airway is influenced by both the asthma status of the subject's mother and the subject's genotype.