Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) is a bioactive peptide that is related to cardiovascular disease such as atherosclerosis, whereas angiotensin-(1-7) (Ang-(1-7)) is a counter-regulator of angiotensin II, which protects against cardiovascular disease. 28283184 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis. 28062506 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE In this study we explored the microRNAs responsible for the regulation of PAI-1 during LPS-stimulated inflammation in human aortic endothelial cells and subsequently studied the effect of a newly synthesized mitochondria-targeted esculetin (Mito-Esc) that was shown for its anti-atherosclerotic potential, in modulating PAI-1 levels and its targeted miRs during angiotensin-II-induced atherosclerosis in ApoE<sup>-/-</sup> mice. 28213977 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Hypoxia in HCASMCs increases leptin expression through the induction of AngII, ROS, and the JNK pathway to enhance atherosclerosis in HCASMCs. 25573199 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (AngII) type 1 receptor (AT1R) blockers have been proved to reduce atherosclerosis. 26771341 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). 24942509 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Previous studies have reported important roles of endothelin-1 (ET-1) and angiotensin II (Ang II) in the pathogenesis of atherosclerosis. 24877885 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Interestingly, in a model of enhanced vascular inflammation using angiotensin II, P2Y(6) deficiency enhanced formation of aneurysms and exhibited a trend towards increased atherosclerosis in the aorta of LDLR knockout mice. 25360548 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Additionally, lncRNAs have been associated with angiotensin II actions and with vascular diseases, including coronary heart disease and atherosclerosis. miRNAs, well studied in various vascular diseases, have also been recently shown to be differentially expressed in the biofluids of patients with vascular disease and mediate cell-cell communication. 24614861 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Therapeutic disease RGD Transfection with GPE nanoparticle carrying AGT shRNA can stably lower the blood pressure and improve the atherosclerotic lesions which lead to the delayed development of early atherosclerotic lesions in hypertension rats with concomitant atherosclerosis. 22977667 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population. 23497386 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Therapeutic disease RGD Hypertension and atherosclerosis rats were treated with GPE nanoparticles carrying AGT shRNA. 22977667 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease CTD_human The purpose of this study was to test the hypothesis that administration of PCB77 to male apolipoprotein E (ApoE) -/- mice promotes AngII-induced atherosclerosis and AAA formation. 21925196 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE During active disease, patients with granulomatosis with polyangiitis (GPA; Wegener's granulomatosis) have accelerated atherosclerosis and ANGII inhibitors are recommended to these patients to reduce atherosclerosis. 21936613 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease CTD_human Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. 22539767 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease CTD_human These results demonstrate that PCB77 augments AngII-induced atherosclerosis and AAA formation. 21925196 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease CTD_human Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice. 21925196 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease CTD_human Infusion of angiotensin II (AngII) to hyperlipidemic mice augments atherosclerosis and causes formation of abdominal aortic aneurysms (AAAs). 21925196 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE However, endothelial-specific Nox2 overexpression did not alter native or angiotensin II-driven atherosclerosis in either the aortic root or the descending aorta. 22287576 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) stimulates vascular smooth muscle cell (VSMC) hypertrophy as a critical event in the development of vascular diseases such as atherosclerosis. 21118843 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Difference in angiotensinogen haplotype frequencies between chronic heart failure and advanced atherosclerosis patients - new prognostic factor? 20945963 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Regulator of G-protein signaling 2 (RGS2) is a key molecule in signal pathways of vasoactive peptides, such as angiotensin II and endothelin 1, and is believed to have an important role in the pathophysiology of atherosclerosis. 21451528 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Th17 response promotes angiotensin II-induced atherosclerosis. 21292406 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE To further elucidate the role of COUP-TFII, we performed DNA microarrays in VEC transfected with the siRNA of COUP-TFII and subsequently stimulated with angiotensin II (AngII) and compared the expression profiles of 112 genes involved in various atherosclerosis-related pathways. 21069739 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE The atherosclerosis-enhancing effects of angiotensin II are complex and incompletely understood. 20504763 2010