| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | The findings of the present study indicated that PEDF may trigger autophagy in HUVECs by inducing p53 and sestrin2 expression, and inhibiting mTOR expression; these findings may contribute to the improved understanding of diseases, including cancer and atherosclerosis. | 31173218 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Inhibitors of mTOR complex 1 (mTORC1) reduced atherosclerosis in preclinical studies, but side effects including insulin resistance and dyslipidemia limit their clinical use in this context. | 31728028 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | The mammalian target of rapamycin (mTOR) and NF-<i>κ</i>B signaling pathways were targeted by the active chemical compounds of GBE to attenuate AS predicted by network pharmacology. | 31080547 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | This study evaluated whether the mTOR inhibitor everolimus can stabilize pre-existing plaques, prevent cardiovascular complications and improve survival in a mouse model of advanced atherosclerosis. | 30590134 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Thus, the mTOR inhibitors may be a promising target for the prevention and treatment of AS. | 30259816 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Mammalian target of rapamycin (mTOR) plays an important role in atherosclerosis in rat vascular smooth muscle cells. | 29605039 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In this study, we engineered a cerium oxide nanowire (CeO<sub>2</sub> NW)-based RNA interference (RNAi) oligonucleotide delivery nanoplatform for the effective silencing of mTOR and treatment of atherosclerosis. | 29629115 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In this model, administration of the siRNA-MR-1 substantially attenuated Ang II-accelerated atherosclerosis with stabilization of atherosclerotic plaques and inhibited FAK, Akt, mammalian target of rapamycin (mTOR) and NF-kB activation, which was associated with suppression of inflammatory factor and atherogenic gene expression in the artery. | 29520165 | 2018 |