Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule-1 (ICAM-1) displays an important role in the development of the inflammation reaction and atherosclerosis. 26078712 2016
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). 24942509 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule‑1 (ICAM‑1) is an important adhesion molecule that has a crucial role in lymphocyte migration and atherosclerosis pathogenesis activation. 24993975 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule-1 (ICAM-1), an important immune adhesion molecule, is related to the atherosclerosis. 25310099 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE We found that SAA (80μg/mL) induced 3.5- to 37.8-fold increases in the expression of targets known to play important roles in the initiation and progression of atherosclerosis (i.e., ICAM-1, MCP-1, MMP-9 and TF) via NF-κB regulation within one hour after exposure. 24785395 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE These results suggest that Trx1 inherently suppresses VCAM-1 and ICAM-1 expression in vascular endothelia and may prevent the initiation of atherosclerosis by attenuating adhesion molecule expression. 24086714 2014
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE ICAM-1-mediated adhesion of leukocytes in vessel walls plays an important role in the pathogenesis of atherosclerosis. 24792184 2014
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE By integrating human and mouse results, we predict that PPAP2B, GALNT4, MAPKAPK5, TCTN1, SRR, SNF8, and ICAM1 play a causal role in the susceptibility to atherosclerosis through a role in the vasculature. 23667179 2014
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE This study demonstrated that DTD could inhibit the expression of ICAM-1, by significantly preventing the activation of JNK and p38, which are important factors of atherosclerosis. 22762513 2013
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation disease BEFREE Genetic variations in E-selectin and ICAM-1: relation to atherosclerosis. 22648254 2012
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation disease BEFREE Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis. 21392767 2011
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE Finally, PCA administration in the apolipoprotein E (ApoE)-deficient mouse model reduced aortic VCAM-1 and ICAM-1 expression, NF-κB activity, and plasma-soluble VCAM-1 and ICAM-1 levels, with inhibiting atherosclerosis development. 21090717 2011
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Further, lipoxygenase pathway SNPs that were associated with measures of atherosclerosis were associated with markers of inflammation (CRP, ICAM-1) and calcification (MGP). 20592751 2010
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE K(1-5) reduced atherosclerosis and neointima formation in mice, possibly through inhibition of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression in endothelial cells. 19874473 2010
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation disease BEFREE Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis. 18420209 2009
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation disease BEFREE ICAM1 variations have been associated with plasma soluble ICAM1 concentrations and inflammatory conditions, including atherosclerosis. 17962597 2008
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE We studied how the levels of intercellular adhesion molecule-1 (ICAM-1), one of the key molecules in the development of atherosclerosis, might be affected by paeonol in tumor necrosis factor-alpha (TNF-alpha)-activated human umbilical vein endothelial cells (HUVECs). 17276892 2007
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE The results proved that PMS is a powerful agent against atherosclerosis and that PMS action could possibly be through the inhibition of the expression of ICAM-1 and VEGF in foam cells. 16276035 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation disease LHGDN ICAM-1 variants may modulate atherosclerosis in humans/gene polymorphisms may influence atherosclerosis independent of plasma levels of their gene products. 15682683 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease LHGDN The ICAM-1 is key molecule in immune-mediated and inflammatory processes and are thus critically involved in diverse clinical disorders, ranging from asthma to atherosclerosis. 15548573 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE Furthermore, ICAM-1 is overexpressed in atherosclerosis, an age-related, chronic inflammatory disease. 15711569 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation disease BEFREE In conclusion, K469E polymorphism of the ICAM-1 gene had impact on plasma fibrinogen level independently of other clinical factors in 360 type 2 diabetic patients, suggesting that fibrinogen is a candidate which links the ICAM-1 gene polymorphism to atherosclerosis. 15736117 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 GeneticVariation disease BEFREE These studies suggest that ICAM-1 variants may modulate atherosclerosis in humans and provide support for the concept that inflammatory gene polymorphisms may influence atherosclerosis independent of plasma levels of their gene products. 15682683 2005
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease CTD_human Atheroprotective Mechanisms Activated by Fluid Shear Stress in Endothelial Cells. 12677255 2003
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule-1 (ICAM-1) plays a crucial role in lymphocyte migration and activation, and is considered important in the pathogenesis of atherosclerosis. 12192299 2003