Gene: RELN ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease BEFREE The RELN gene, which codes for an extracellular protein guiding neuronal migration, has been implicated in autism. 12583844 2003
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease CTD_human Our results strengthen the case for a more detailed study of the role of RELN and GRIK2 in autism susceptibility, as well as identifying two new potential candidate genes, MKL2 and SND1. 20442744 2010
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease CTD_human Our findings suggest that longer triplet repeats in the 5'UTR of the RELN gene confer vulnerability to autistic disorder. 11317216 2001
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease BEFREE Reelin had been proposed to participate in the etiology of autism due to its important role in brain development. 26285919 2016
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease BEFREE Our findings support a role for the Reelin gene in the susceptibility to autism. 16311013 2006
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease BEFREE Quantification of Reelin bands showed 43%, 44%, and 44% reductions in autistic cerebellum (mean optical density +/- SD per 30 microg protein 4.05 +/- 4.0, 1.98 +/- 2.0, 13.88 +/- 11.9 for 410 kDa, 330 kDa, and 180 kDa bands, respectively; N = 5) compared with controls (mean optical density +/- SD per 30 microg protein, 7.1 +/- 1.6, 3.5 +/- 1.0, 24.7 +/- 5.0; N = 8, p < 0.0402 for 180 kDa band). 11814262 2001
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease CTD_human Quantification of Reelin bands showed 43%, 44%, and 44% reductions in autistic cerebellum (mean optical density +/- SD per 30 microg protein 4.05 +/- 4.0, 1.98 +/- 2.0, 13.88 +/- 11.9 for 410 kDa, 330 kDa, and 180 kDa bands, respectively; N = 5) compared with controls (mean optical density +/- SD per 30 microg protein, 7.1 +/- 1.6, 3.5 +/- 1.0, 24.7 +/- 5.0; N = 8, p < 0.0402 for 180 kDa band). 11814262 2001
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 Biomarker disease BEFREE Several studies have reported evidence for an association between autism and the Reelin gene. 14755445 2004
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 AlteredExpression disease BEFREE Several reports suggest that reduced reelin expression is associated with human mental illnesses such as schizophrenia, mood disorders and autism. 16556465 2006
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.400 AlteredExpression disease BEFREE Excessive RELN promoter methylation and/or decreased RELN gene expression have been described in schizophrenia and autism. 19952965 2010