Our studies in bladder cancer and lung adenocarcinoma have demonstrated a crucial role of YAP1, a transcriptional regulator of genes that promote cell survival and proliferation, in regulating CSC phenotypes.
An orthotopic bladder cancer mouse model was established to evaluate the <i>in vivo</i> effects of a YAP inhibitor (verteporfin) and a PDGFR inhibitor (CP-673451) on the <i>cis</i>-platinum resistance of OV6<sup>+</sup> CSCs in bladder cancer.
To address the repressive function of VP against YAP in bladder cancer, we check the target genes' expression and find VP can dramatically repress YAP overexpression induced Hippo pathway target genes' expression.
Thus, our data indicates that curcumin promotes KLF5 proteasome-dependent degradation through targeting YAP/TAZ in bladder cancer cells and also suggests the therapeutic potential of curcumin in the treatment of bladder cancer.