SERPINE1
|
0.080 |
Biomarker
|
group |
BEFREE |
: Complete plasminogen activator inhibitor-1 (PAI-1) deficiency is a very rare genetic disorder that is associated with an increased risk of bleeding diathesis.
|
31743119 |
2020 |
SERPINE1
|
0.080 |
Biomarker
|
group |
BEFREE |
HIV/HCV-coinfected patients had higher biomarker levels of immune activation in peripheral blood [T-cell activation (CD4CD38 and CD8CD38), bacterial translocation (soluble CD14), inflammation [IL-1b, IL-6, IL-8, IL-18, IFN-γ-inducible protein 10 (IP-10)] endothelial dysfunction [soluble vascular cell adhesion molecule 1 (sVCAM1), soluble intercellular cell adhesion molecule 1 (sICAM1), and soluble tumor necrosis factor receptor 1 (sTNFR1)], and coagulopathy (plasminogen activator inhibitor-1)] than healthy controls and HIV-monoinfected patients.
|
29438197 |
2018 |
SERPINE1
|
0.080 |
AlteredExpression
|
group |
BEFREE |
A profibrinolytic coagulopathy phenotype was demonstrated in all subgroups with increased tissue plasminogen activator levels and decreased plasminogen activator inhibitor-1 levels.
|
29538236 |
2018 |
SERPINE1
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Traumatic injury is associated with an increased risk of coagulopathy and venous thrombosis. plasminogen activator inhibitor-1 (PAI-1) is a procoagulant molecule that inhibits tPA/uPA, thrombomodulin, and activated protein C. We hypothesized that elevated PAI-1 levels would be associated with increased Injury Severity Score (ISS) in injured patients with and without traumatic brain injury and that PAI-1 levels would vary with injury type.
|
30086072 |
2018 |
SERPINE1
|
0.080 |
GeneticVariation
|
group |
BEFREE |
To investigate whether plasminogen activator inhibitor-1 (PAI-1) level influences the variation in bleeding tendency in VWD patients.
|
28306198 |
2017 |
SERPINE1
|
0.080 |
Biomarker
|
group |
BEFREE |
Using a murine model of severe TBI, we found that ICH is reduced in tPA(-/-) and uPA(-/-) mice but increased in PAI-1(-/-) mice compared with wild-type (WT) mice. tPA(-/-), but not uPA(-/-), mice developed a systemic coagulopathy post-TBI.
|
25673638 |
2015 |
SERPINE1
|
0.080 |
Biomarker
|
group |
BEFREE |
Clear documentation of PAI-1 deficiency as a cause of a bleeding disorder has been rare.
|
19141166 |
2008 |
SERPINE1
|
0.080 |
Biomarker
|
group |
BEFREE |
Hereditary partial deficiency of plasminogen activator inhibitor-1 associated with a lifelong bleeding tendency.
|
8757969 |
1996 |