| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | group | BEFREE | Our group has developed a therapeutic platform to target IL13Rα2-positive brain tumors by engineering human cytotoxic T lymphocytes (CTLs) to express the IL13-zetakine chimeric antigen receptor. | 24787244 | 2014 | ||||
|
0.080 | AlteredExpression | group | BEFREE | We have taken a bioinformatics approach towards understanding the biological context of IL-13 receptor α2 (IL13Rα2) expression in brain tumors, and its functional significance for patient survival. | 24204956 | 2013 | ||||
|
0.080 | Biomarker | group | BEFREE | Recent studies show that interleukin-13 receptor [alpha]2 chain (IL-13Ra2), a brain tumor-associated receptor for IL-13, may play a role in immunotherapy for glioblastoma. | 18677476 | 2009 | ||||
|
0.080 | Biomarker | group | BEFREE | Although IL13-PE38 is being tested in a Phase III clinical trial in brain tumors, the activity of IL13-PE38 alone or when combined with taxane, a chemotherapeutic drug for oral squamous cell carcinoma (OSCC), has not been investigated. | 19065664 | 2009 | ||||
|
0.080 | Biomarker | group | BEFREE | A bispecific immunotoxin (IT) called DTAT13 was synthesized in order to target simultaneously the urokinase-type plasminogen activator receptor (uPAR)-expressing tumor neovasculature and IL-13 receptor expressing glioblastoma cells with the goal of intratumoral administration for brain tumors. | 15047912 | 2004 | ||||
|
0.080 | Biomarker | group | BEFREE | The fact, that IL-13Ralpha2-positive cells bind IL-13 independent of IL-4, become susceptible to IL-13 cytotoxins, and cells deprived of IL-13Ralpha2 receptor lose these features, demonstrates that IL-13Ralpha2 is the brain tumor-associated receptor for IL-13. | 12192597 | 2003 | ||||
|
0.080 | Biomarker | group | BEFREE | We now extend this analysis to evaluate the distribution of the binding of IL13 among other brain tumors. | 11083073 | 2000 | ||||
|
0.080 | Biomarker | group | BEFREE | Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen. | 10952023 | 2000 |