|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we compared Oct4 expression in MCF-7 and MDA-MB-231 cells, two breast cancer cell lines with similar epithelial origins, but distinct invasive and metastatic characteristics.
|
21798248 |
2011 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
OCT4 expression and vasculogenic mimicry formation positively correlate with poor prognosis in human breast cancer.
|
25353179 |
2014 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation.
|
28614911 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Regulation of CHIP expression and OCT4 protein stability is a considerable approach for breast cancer therapy.
|
29511337 |
2018 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Administration of paricalcitol leads to upregulation of JMJD3 that suppresses Oct4 expression and the stem cell-like characteristics in breast cancer.
|
28423536 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we observed that the expression of Oct-4 protein was related to histological type, lymph node status and molecular type of breast cancer (P = 0.001, 0.006, and 0.001, respectively).
|
21394007 |
2011 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis by qPCR, ELISA, western blot, immunofluorescence staining, sphere formation, colony assay, transwell migration, and invasion assays demonstrated rBmK AGAP treatment decreased the expressions of Oct4, Sox2, N-cadherin, Snail, and increased the expression of E-cadherin. rBmK AGAP inhibited breast cancer cell stemness, EMT, migration, and invasion by down-regulating PTX3 through NF-κB and Wnt/β-catenin signaling Pathway <i>in vitro</i> and <i>in vivo</i>.
|
30740360 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In our study, we show that, in vitro, almost all murine Lewis lung carcinoma 3LL cells and human breast cancer MCF7 cells express Oct4 at high levels.
|
18701476 |
2008 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of BRCA1, BRCA2, and Bod1 in miR-142-3p-overexpressing cells as well as expression of miR-142-3p, Bod1, KLF4, and Oct4 in sorted CD44<sup>+</sup>/CD24<sup>-/low</sup> cells were determined by quantitative polymerase chain reaction. miR-142-3p overexpression resulted in a strong decline in breast cancer stem cell characteristics with a decrease in CD44, CD133, ALDH1, Bod1, BRCA2, and mammosphere formation as well as reduced survival after irradiation. miR-142-3p expression was strongly reduced in sorted CD44<sup>+</sup>/CD24<sup>-/low</sup> stem cells, while Bod1, Oct4, and KLF4 were overexpressed.
|
30091683 |
2018 |