Overall, our results found that only AA genotype of the XRCC1 gene Arg399Gln polymorphism under the homozygous model was associated with increased the risk of patients with laryngeal cancer (AA vs. GG: OR=1.29, 95% CI=1.00-1.65, P=0.05).
In conclusion, the results of our study suggest that the AA genotype and A allele of the XRCC1Arg280His polymorphism are associated with an increased laryngeal cancer risk in a Chinese population.