×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
Transglutaminase 2 (TGase 2 ) plays a key role in p53 regulation, depleting p53 tumor suppressor through autophagy in renal cell carcinoma .
30231606
2019
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
This suggests that RCC survival can be stopped by p53-induced cell death through blocking the p53-TGase 2 complex formation using GK921.
30105541
2018
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
Therefore, combined targeting of TG2 with drugs widely used in the treatment of RCC may be a promising therapeutic strategy for RCC .
28498731
2018
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
Inhibition of TGase 2 using streptonigrin increased p53 stability, which resulted in p53-mediated apoptosis of RCC .
30463244
2018
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
Meanwhile, other small molecule therapies for RCC that target indoleamine-2,3-dioxygenase (IDO1), glutaminase, C-X-C chemokine receptor 4 (CXCR4), and transglutaminase 2 (TG2 ) are emerging as the next generation of therapeutics.
28844802
2017
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
Combination therapy with a TGase 2 inhibitor and a DNA-damaging agent may represent an effective therapeutic approach for treating RCC .
27031960
2016
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
AlteredExpression
disease
BEFREE
The expression of TGase 2 is markedly increased in most RCC cell lines, as well as in clinical samples.
24610445
2014
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
AlteredExpression
disease
BEFREE
This finding implies that induced expression of TGase 2 promotes tumor cell survival through p53 depletion in RCC .
23704086
2013
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
Downregulation of tumor suppressive miR-1285, which targets oncogenic genes including TGM2 , might contribute to RCC development.
22294552
2012
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
BEFREE
The remaining seven genes had unmethylated promoters, although at least one of these genes (TGM2 ) may be regulated by RASSF1A, which was methylated in the RCC lines.
16707423
2006
×
Entrez Id:
7052
Gene Symbol:
TGM2
TGM2
0.400
Biomarker
disease
CTD_human
Differential protein profiling in renal-cell carcinoma.
15108329
2004