Gene: BAG3 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 Biomarker group HPO
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 Biomarker group MGD
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. 21898660 2011
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group GWASDB A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. 21459883 2011
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 CausalMutation group CLINVAR A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. 21459883 2011
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group GWASCAT A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. 21459883 2011
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group CLINVAR A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. 21459883 2011
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE At least 10 other Bag3 mutations have been reported, nine resulting in a dilated cardiomyopathy for which no specific therapy is available. 27321750 2016
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group CLINVAR BAG3 myofibrillar myopathy presenting with cardiomyopathy. 25728519 2015
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group CLINVAR BAG3: a new player in the heart failure paradigm. 25925243 2015
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Deletions and truncations in BAG3 that result in haplo-insufficiency have been associated with the development of dilated cardiomyopathy. 29323723 2018
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 AlteredExpression group BEFREE Diminished levels of BAG3 protein may be associated with both familial and non-familial forms of dilated cardiomyopathy. 24623017 2014
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 CausalMutation group CLINVAR Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era. 22337857 2012
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. 21353195 2011
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group CLINVAR Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. 21353195 2011
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Here, we studied whether a clinical association between BAG3-related FDCM and circulating miRNAs may have diagnostic and prognostic value in a small cohort of familial related individuals carrying a BAG3 mutation (BAG3+) and/or diagnosed of dilated cardiomyopathy (DCM) (DCM+). 30792263 2019
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 Biomarker group BEFREE In this issue of the JCI, Fang and colleagues demonstrate that mice with cardiac-specific deficiency of the co-chaperone protein BCL2-associated athanogene 3 (BAG3) develop dilated cardiomyopathy that is associated with a destabilization of small HSPs as the result of a disrupted interaction between BAG3 and HSP70. 28737514 2017
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes. 31723063 2019
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 CausalMutation group CLINVAR Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. 28737513 2017
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Mutation and downregulation of the co-chaperone protein BCL-2-associated athanogene 3 (BAG3) are associated with cardiac myopathy and heart failure, and a BAG3 E455K mutation leads to dilated cardiomyopathy (DCM). 28737513 2017
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Mutations of BAG3 have been implicated in the pathogenesis of cardiac complications such as dilated cardiomyopathy. 30932190 2019
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians. 25448463 2014
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 CausalMutation group CLINVAR Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians. 25448463 2014
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE Novel Genetic Variants in BAG3 and TNNT2 in a Swedish Family with a History of Dilated Cardiomyopathy and Sudden Cardiac Death. 28669108 2017
Entrez Id: 9531
Gene Symbol: BAG3
BAG3 		0.400 GeneticVariation group BEFREE The BAG3 gene variants in Polish patients with dilated cardiomyopathy: four novel mutations and a genotype-phenotype correlation. 25008357 2014