Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5376
Gene Symbol: PMP22
PMP22
0.010 GeneticVariation group BEFREE In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p = .06). 31543086 2020
Entrez Id: 4359
Gene Symbol: MPZ
MPZ
0.010 GeneticVariation group BEFREE In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p = .06). 31543086 2020
Entrez Id: 10468
Gene Symbol: FST
FST
0.010 GeneticVariation group BEFREE Five of six eQTL genes are among the top candidate causal genes and the abnormal expression levels of these genes (IRS-1, GRB14, FST, PEPD and PDGFC) in human SAT could be associated with increased risk of IR, T2D and CVD. 31739742 2020
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.010 Biomarker group BEFREE Impact of zinc oxide nanoparticles on thioredoxin-interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma-irradiated rats. 31749214 2020
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.010 Biomarker group BEFREE Finally, we consider the most recent evidence on the role of dynorphin during cardiovascular-related inflammation and on the potential value of endogenous and exogenous inhibitors of kappa-opioid receptor, a major dynorphin A receptor, to limit or prevent cardiovascular disease and its related sequelae. 31746302 2020
Entrez Id: 11343
Gene Symbol: MGLL
MGLL
0.010 Biomarker group BEFREE The serine hydrolase monoacylglycerol lipase (MAGL) is involved in a plethora of pathological conditions, in particular pain and inflammation, various types of cancer, metabolic, neurological and cardiovascular disorders, and is therefore a promising target for drug development. 31668797 2020
Entrez Id: 64689
Gene Symbol: GORASP1
GORASP1
0.010 Biomarker group BEFREE Regulation of the TLR4 pathway, as well as its downstream NF-κB p65 and p38 MAPK pathways, may be an effective strategy for the prevention and treatment of cardiovascular diseases. 31494123 2020
Entrez Id: 9068
Gene Symbol: ANGPTL1
ANGPTL1
0.010 Biomarker group BEFREE These findings impart key information for the understanding of Ang III functions, especially in VSMCs and possible cardiovascular diseases. 31738968 2020
Entrez Id: 190
Gene Symbol: NR0B1
NR0B1
0.010 GeneticVariation group BEFREE In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p = .06). 31543086 2020
Entrez Id: 5184
Gene Symbol: PEPD
PEPD
0.010 Biomarker group BEFREE Five of six eQTL genes are among the top candidate causal genes and the abnormal expression levels of these genes (IRS-1, GRB14, FST, PEPD and PDGFC) in human SAT could be associated with increased risk of IR, T2D and CVD. 31739742 2020
Entrez Id: 9332
Gene Symbol: CD163
CD163
0.010 Biomarker group BEFREE Soluble CD163 is a biomarker for accelerated atherosclerosis in systemic lupus erythematosus patients at apparent low risk for cardiovascular disease. 31161842 2020
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.010 Biomarker group BEFREE Regulation of the TLR4 pathway, as well as its downstream NF-κB p65 and p38 MAPK pathways, may be an effective strategy for the prevention and treatment of cardiovascular diseases. 31494123 2020
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.010 Biomarker group BEFREE Recent studies have reported that acetylcholinesterase inhibitors improve autonomic function and cardiac function in cardiovascular disease models. 31595611 2020
Entrez Id: 3299
Gene Symbol: HSF4
HSF4
0.010 Biomarker group BEFREE We also applied CTM to construct a novel ECL immunosensor and achieve the sensitive detection of the proprotein convertase subtilisin/kexin type 9 (PCSK9), a biomarker related to cardiovascular diseases (CVDs). 31794188 2020
Entrez Id: 8165
Gene Symbol: AKAP1
AKAP1
0.010 Biomarker group BEFREE A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases. 31783032 2020
Entrez Id: 51378
Gene Symbol: ANGPT4
ANGPT4
0.010 Biomarker group BEFREE These findings impart key information for the understanding of Ang III functions, especially in VSMCs and possible cardiovascular diseases. 31738968 2020
Entrez Id: 823
Gene Symbol: CAPN1
CAPN1
0.010 AlteredExpression group BEFREE MMP-2 activity may be regulated by calpain-1 via bioactive molecules activation such as transforming growth factor (TGF)-β in cardiovascular diseases. 31830479 2020
Entrez Id: 107987479
Gene Symbol: LOC107987479
LOC107987479
0.010 Biomarker group BEFREE Cytochrome P450 2D6 (CYP2D6) and endothelial nitric oxide synthase (eNOS) are important in the cardiovascular disease susceptibility and drug response. 31616043 2020
Entrez Id: 728378
Gene Symbol: POTEF
POTEF
0.010 Biomarker group BEFREE β-actin (ACTB) participates in the vascular remodeling and contributes to the cardiovascular diseases. 31327802 2020
Entrez Id: 7474
Gene Symbol: WNT5A
WNT5A
0.010 Biomarker group BEFREE Accumulating evidence has demonstrated that Wingless type 5a (Wnt5a) is implicated in cardiovascular diseases through non-canonical Wnt cascades. 31678514 2020
Entrez Id: 6857
Gene Symbol: SYT1
SYT1
0.010 Biomarker group BEFREE Regulation of the TLR4 pathway, as well as its downstream NF-κB p65 and p38 MAPK pathways, may be an effective strategy for the prevention and treatment of cardiovascular diseases. 31494123 2020
Entrez Id: 51473
Gene Symbol: DCDC2
DCDC2
0.010 GeneticVariation group BEFREE Based on the NHIS-NSC data, patients with scrub typhus are at greater risk of developing cardiovascular disease long term compared with that of the general population. 31776872 2020
Entrez Id: 151888
Gene Symbol: BTLA
BTLA
0.010 AlteredExpression group BEFREE We show that BTLA is primarily expressed on B cells in CVD patients and follicular B2 cells in low-density lipoprotein receptor-deficient (Ldlr-/-) mice. 31150053 2020
Entrez Id: 608
Gene Symbol: TNFRSF17
TNFRSF17
0.010 Biomarker group BEFREE Some of the claimed negative health outcomes associated with milk consumption, such as cardiovascular diseases and type 1 diabetes may be attributed to an opioid peptide, beta-casomorphin-7 (BCM-7), derived from A1 beta-casein. 31154909 2020
Entrez Id: 7809
Gene Symbol: BSND
BSND
0.010 GeneticVariation group BEFREE In adjusted Cox models, both BART - LVH and cardiac magnetic resonance imaging- LVH were associated with mortality (hazard ratio [95% CI ], 1.88 [1.45-2.44] and 2.21 [1.74-2.81], respectively), cardiovascular disease events (hazard ratio [95% CI ], 1.46 [1.08-1.98] and 1.91 [1.46-2.51], respectively), and coronary heart disease events (hazard ratio [95% CI ], 1.72 [1.20-2.47] and 1.96 [1.41-2.73], respectively). 30827132 2019