| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | group | BEFREE | In a nested case-control study of 55 PWH with first-time Myocardial Infarction (MI) (cases) and 182 PWH with no CVD (controls), we measured soluble markers of IL-1 activation at 4 different timepoints before the case´s MI. | 31077280 | 2020 | ||||
|
0.090 | Biomarker | group | BEFREE | We discuss clinical evidence, experimental approaches and lastly lend a perspective on currently developing therapeutic strategies involving the IL-1 family in CVD. | 29198612 | 2019 | ||||
|
0.090 | AlteredExpression | group | BEFREE | The mean serum level of TNF-α and IL1-α were 32.16 pg/ml and 6.64 pg/ml in CVD patient. | 31485173 | 2019 | ||||
|
0.090 | Biomarker | group | BEFREE | Most advanced are clinical studies with IL-1 antagonists showing improved β-cell function and glycemia and prevention of cardiovascular diseases and heart failure. | 31127805 | 2019 | ||||
|
0.090 | GeneticVariation | group | BEFREE | These data suggest that the dual genetic contributions of elevated Lp(a) levels and IL-1(+) genotypes may identify younger subjects at particularly high risk for CVD events. | 29310992 | 2019 | ||||
|
0.090 | Biomarker | group | BEFREE | Blocking the IL-1 pathway is a possible new therapeutic strategy, potentially leading to innovative therapies in many acute and chronic cardiovascular diseases. | 29904899 | 2018 | ||||
|
0.090 | GeneticVariation | group | BEFREE | The hyperglycemia can directly promote an inflammatory state where the increase C-reactive (CRP) and cytokines, such as interleukins (IL-1 and IL-6), which contribute to the development of cardiovascular diseases. | 28939513 | 2018 | ||||
|
0.090 | Biomarker | group | BEFREE | Hypothetical models are presented to explain how IL-1 genetic factors may be involved in cardiovascular disease. | 10685360 | 1999 | ||||
|
0.090 | Biomarker | group | BEFREE | Although it has been suggested that cytokines are involved in pathogenesis of cardiovascular diseases only few informations exist regarding the endogenous production and function of IL-1 and the associated enzyme(s) of the caspase family in the cardiovascular system. | 9889413 | 1998 |