| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | group | BEFREE | In the past few years, the Paraoxonase multigene family (<i>PON1, PON2, PON3</i>) has been shown to play an important role in pathogenesis of cardiovascular disorders including coronary artery disease (CAD). | 31816846 | 2019 | ||||
|
0.370 | Biomarker | group | BEFREE | Supporting a direct role for PON2 in cardiovascular diseases, <i>Pon2</i> deficiency in mice promotes atherogenesis through incompletely understood mechanisms. | 29439952 | 2018 | ||||
|
0.370 | AlteredExpression | group | BEFREE | The higher levels of PON2 in females may explain the lower frequency of neurological and cardiovascular diseases in females and the ability to identify males but not females with Parkinson's disease using a special PON1 status assay. | 27238723 | 2016 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Large-scale epidemiologic studies are needed to further examine the relationship between PON2 genetic polymorphisms and risk for CVD. | 19474728 | 2009 | ||||
|
0.370 | Biomarker | group | CTD_human | Synergistic effect of polymorphisms of paraoxonase gene cluster and arsenic exposure on electrocardiogram abnormality. | 19152805 | 2009 | ||||
|
0.370 | Biomarker | group | BEFREE | Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases. | 19082953 | 2008 | ||||
|
0.370 | GeneticVariation | group | BEFREE | (1,2) The PON1 activity and the polymorphism of the PON1 and PON2 genes have been found to be associated with risk of cardiovascular diseases such as hypercholesterolaemia, non-insulin-dependent diabetes, coronary heart disease (CHD) and myocardial infaction. | 11803456 | 2002 | ||||
|
0.370 | GeneticVariation | group | BEFREE | In our study we assessed the frequency and genotype distribution of the PON1 and PON2 polymorphisms in 197 patients with familial hypercholesterolemia (FH), to determine the possible association between these mutations and susceptibility for CVD. | 11257265 | 2001 |