| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | GeneticVariation | group | BEFREE | Studies of sortilin's influence on cardiovascular and metabolic diseases goes far beyond the genome-wide association studies that have revealed an association between cardiovascular diseases and the 1p13 locus that encodes sortilin. | 29191923 | 2018 | ||||
|
0.380 | Biomarker | group | BEFREE | Together our findings support a novel role of Sortilin in energy regulation and lipid homeostasis in female mice, which may be a potential therapeutic target for obesity and cardiovascular disease. | 29899496 | 2018 | ||||
|
0.380 | Biomarker | group | BEFREE | Sortilin-1, a receptor of the VPS10p family, has been associated with cardiovascular disease in genome-wide association studies. | 28742217 | 2017 | ||||
|
0.380 | Biomarker | group | BEFREE | The fact that SORT1 has been strongly associated with risk of cardiovascular disease is intriguing as cardiovascular disease is also regarded as a risk factor for AD. | 27392867 | 2016 | ||||
|
0.380 | GeneticVariation | group | BEFREE | Primary outcome of interest was incident hard CVD (myocardial infarction, stroke, and cardiovascular death); interaction between proneurotensin concentration with sex, low-density lipoprotein concentrations, and sortilin receptor 1 single-nucleotide polymorphisms was sought. | 27312221 | 2016 | ||||
|
0.380 | Biomarker | group | BEFREE | Sortilin seems to play an important role in the development of cardiovascular disease and have functions beyond regulating LDL-cholesterol. | 25702058 | 2015 | ||||
|
0.380 | Biomarker | group | CTD_human | Genetic variation of SORT1 was strongly associated with cardiovascular disease risk in humans. | 25805502 | 2015 | ||||
|
0.380 | GeneticVariation | group | BEFREE | These results provide evidence of decreased exposure to atherogenic particles in carriers of the minor SORT1 allele, suggesting relative protection against cardiovascular disease when compared with TT homozygotes. | 25042869 | 2014 | ||||
|
0.380 | Biomarker | group | BEFREE | Sortilin and the risk of cardiovascular disease. | 23910371 | 2013 |