Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease CTD_human
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice. 408 1975
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. 489978 1979
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Formation of anomalous lysosomes in monocytes, neutrophils, and eosinophils from bone marrow of mice with Chédiak-Higashi syndrome. 1113502 1975
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Cytoarchitectonic abnormalities in cerebellum and hippocampal formation of beige mutant mouse. 1523694 1992
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Lysosomal mutations increase susceptibility to anaesthetics. 2513223 1989
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD The beige mouse: role of neutrophil elastase in the development of pulmonary emphysema. 2806196 1989
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2 		0.010 GeneticVariation disease BEFREE In three families, RFLPs in TCR-gamma genes were inherited discordantly from Chediak-Higashi syndrome, demonstrating nonlinkage. 2895730 1987
Entrez Id: 4353
Gene Symbol: MPO
MPO 		0.010 Biomarker disease BEFREE The most common syndromes are chronic granulomatous disease of childhood (CGD), the Chediak-Higashi syndrome (CHS), the hyperimmunoglobulin-E-recurrent infection (Job's) syndrome (HIE), and myeloperoxidase (MPO) deficiency. 2941193 1986
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl. 3584547 1987
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Distribution of anomalous lysosomes in the beige mouse: a homologue of Chediak-Higashi syndrome. 4697831 1973
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Giant granules in leukocytes of the beige mouse. 5590154 1968
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD The origin and fate of large dense bodies in beige mouse fibroblasts. Lysosomal fusion and exocytosis. 6170520 1981
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Leishmaniasis in beige mice. 6218091 1982
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Defective T-cell response in beige mutant mice. 6977094 1982
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity. 7089489 1982
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Role of NK cells in tumour growth and metastasis in beige mice. 7366733 1980
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease MGD Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice. 7366734 1980
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 GeneticVariation disease BEFREE The homologous human gene, LYST, is highly conserved with mouse Lyst, and contains a frame-shift mutation at nucleotides 117-118 of the coding domain in a CHS patient. 8717042 1996
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease BEFREE Our results indicate that the human CHS gene maps to an 18.8-cM interval in chromosome segment 1q42-q44 and that human CHS therefore is very likely homologous to mouse bg. 8751863 1996
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 CausalMutation disease CLINVAR Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. 8896560 1996
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 Biomarker disease GENOMICS_ENGLAND Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. 8896560 1996
Entrez Id: 1130
Gene Symbol: LYST
LYST 		1.000 GeneticVariation disease CLINVAR Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. 8896560 1996
Entrez Id: 30849
Gene Symbol: PIK3R4
PIK3R4 		0.010 Biomarker disease BEFREE Analysis of the CHS polypeptide demonstrates that its modular architecture is similar to the yeast vacuolar sorting protein, VPS15. 8896560 1996