| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | The purpose of this work was to examine the involvement of G protein-coupled estrogen receptor (GPER), estrogen receptor α (ERα), estrogen receptor β (ERβ) and ERα spliced variants ERα36 and ERα46 in Crohn's disease (CD) and ulcerative colitis (UC). | 31261736 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Studies on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases, such as Crohn's disease and ulcerative colitis. | 31435166 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | We aim to investigate the impact of estrogen receptor gene (<i>ESR1</i>) gene polymorphisms on bone mineral density (BMD) in patients with ulcerative colitis (UC) and Crohn's disease (CD), as they may contribute both, to osteoporosis and inflammatory processes. | 31450614 | 2019 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Decreases in ESR and hs-CRP levels and increase in LL37 gene expression support the hypothesis that Vitamin D supplementation may have a beneficial role in UC patients. | 27488327 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | To assess genomic methylation and promoter methylation of the ESR-1 (oestrogen receptor-1) and N-33 (tumor suppressor candidate-3) genes in the macroscopically normal mucosa of UC patients as well as to investigate effects of anthropometric and lifestyle exposures on DNA methylation. | 20505342 | 2010 | ||||
|
0.070 | Biomarker | disease | BEFREE | B1a cell rate correlated inversely in UC patients with ESR (R = -0.41, p < 0.05) and CRP levels (R = -0.47, p = 0.01). | 17372743 | 2007 | ||||
|
0.070 | PosttranslationalModification | disease | BEFREE | The methylation level of the ER gene in UC patients with neoplasia was significantly higher than in UC patients without neoplasia throughout the colorectum except for the cecum. | 16361578 | 2005 |