Gene: APC ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease UNIPROT
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 CausalMutation disease CLINVAR
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease CLINVAR
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 Biomarker disease CTD_human 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron. 21967605 2011
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE Colorectal cancers commonly carry truncation mutations in the adenomatous polyposis coli (APC) gene. 22399804 2012
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 Biomarker disease BEFREE CRC is a very heterogeneous disease, and with a few exceptions (APC, p53, KRAS), most of the genes involved in CRC are observed in a small percentage of cases. 24944469 2014
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE Colorectal cancer (CRC) is a multistep process based on the accumulation of somatic mutations in genes such as APC and KRAS. 26749281 2016
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 Biomarker disease BEFREE Colorectal cancers show evidence of Wnt signaling pathway activation and this is associated with loss of function of the tumor regulator APC. 29169144 2018
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE Colorectal cancers (CRCs) initiate through distinct mutations, including in APC pathway components leading to tubular adenomas (TAs); in BRAF, with epigenetic silencing of CDX2, leading to serrated adenomas (SAs); and in the DNA mismatch repair machinery driving microsatellite instability (MSI). 30716341 2019
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE Colorectal cancer (CRC) development is characterized by the stepwise accumulation of mutations over time, of which mutations in the tumor suppressor APC are often very early to occur. 30799131 2020
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE Colorectal cancer is a complex disease driven by well-established mutations such as APC and other yet to be identified pathways. 31213502 2019
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC gene mutations have been demonstrated not only in colorectal carcinoma but also in a variety of human cancers. 10381126 1998
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC mutation was not correlated with previous history of colorectal carcinoma or number of polyps. 10502830 1999
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews. 11159880 2001
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC mutation and tumour budding in colorectal cancer. 12499439 2003
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC and K- ras mutations are considered to be early-stage developments of CRCs, whereas p53 mutations are thought to be relatively late events in the tumorigenesis of CRCs. 15185002 2004
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 PosttranslationalModification disease BEFREE APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. 15326380 2004
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 PosttranslationalModification disease BEFREE APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer. 16981189 2006
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 Biomarker disease BEFREE Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in most colorectal cancers. 17293347 2007
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC mutations cause activation of Wnt/beta-catenin signaling, which invariably leads to colorectal cancer. 20663899 2010
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 AlteredExpression disease BEFREE APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation. 23773491 2013
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 Biomarker disease BEFREE APC(Min/+)-Cdx2 mutants recapitulated several aspects of human colorectal cancer, including an invasive phenotype. 25320087 2014
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. 26305864 2015
Entrez Id: 324
Gene Symbol: APC
APC 		0.800 GeneticVariation disease BEFREE APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC) and these mutations cooperatively accelerate tumorigenesis including metastasis. 27835580 2016