Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 GeneticVariation disease BEFREE De novo methylation of CpG sites in exon 2 of the bcl-2 gene occurs during the development of colorectal carcinoma. 11724359 2001
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 GeneticVariation disease BEFREE Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer. 9881495 1998
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 GeneticVariation disease BEFREE In summary, our results show that rs7911488 C-allelic pre-miR-1307 binds to MBNL1 and infers with Dicer processing, leading to reduced miR-1307 and increased Bcl2 expression, thus representing an important process in the initiation of CRC. 25977444 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 GeneticVariation disease BEFREE Bcl-2 rs1800477A/G polymorphism may be related to the occurrence of CRC, and GG genotype could be a risk factor of poor prognosis in CRC. 28106544 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Immunohistochemistry staining was used to assess the expression of paxillin and its association with the expression of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, p53 and Bcl-2 in 102 patients with primary colorectal carcinoma. 24451945 2014
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Our data showed that inhibition of JAK2/STAT3 signalling induced CRC cellular apoptosis via modulating the Bcl-2 gene family, promoting the loss of mitochondrial transmembrane potential (Δψm) and the increase of reactive oxygen species. 22050790 2012
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE The present study aims to design, optimize and validate the qPCR, in accordance with the MIQE (Minimum Information for Publication of Quantitative Real-Time PCR Experiments) guidelines, for seventeen genes commonly used in the DMH/AOM rat model of CRC (<i>Apc, Aurka, Bax, Bcl2, <i>β</i>-catenin, Ccnd1, Cdkn1a, Cox2, Gsk3beta, IL-33, iNOs, Nrf2, p53, RelA, Smad4, Tnfα</i> and <i>Vegfa</i>) and two reference genes (<i>Actb</i> or <i>β</i>-<i>actin</i> and <i>B2m</i>). 30713822 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Neither Bcl-2 or β-catenin were shown to be useful biomarkers for the prognosis of colorectal cancer. 25738398 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Western blot analysis also showed that the expression of proapoptotic proteins (cleaved caspase 3 and cleaved PARP) was upregulated, while that of antiapoptotic proteins (Bcl-2 and survivin) was downregulated after deguelin treatment in CRC cell lines. 30588113 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of supplemental vitamin D3 (1,000 IU/day [25 μg/day]) and calcium (1,200 mg/day), alone and in combination, on biomarkers of proliferation (mib-1), differentiation (p21), and apoptosis (bax [apoptosis-promoting] and bcl-2 [apoptosis-inhibiting]), in the normal-appearing rectal mucosa in a subsample of participants (n = 104) in a larger randomized, double-blind, placebo-controlled clinical trial among colorectal adenoma patients. 30557404 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE The multi-marker phenotype EphB2-/Bcl-2- is an independent predictor of high-grade budding and implies increased aggressive behaviour in MMR-proficient colorectal cancer. 20716165 2010
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Antimycin A3, in combination with SN-38 recapitulated this phenotype in HCT 116 cells, suggesting a potential role for small molecule inhibitors of Bcl-xL/Bcl-2 in the treatment of colorectal cancer, potentially in combination with irinotecan. 17273826 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Bcl-2 was positive in 18.18% of the cases, in distal colorectal cancer, only in men, 63.5 ± 13.2-year-old. 22990545 2012
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. 31296963 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Solasodine was also found to fuel caspase-cascade reaction and increase the ratio between Bax and Bcl-2 so as to induce CRC cell apoptosis. 28803443 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Immunohistochemical expression of p53, mdm-2, waf-1, and bcl-2 is similar for CAC and CRC. 11865380 2002
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE This study revealed functional and mechanistic links between miRNA-30b and oncogene KRAS, PIK3CD and BCL2 in the pathogenesis of CRC. 24293274 2014
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE 1) Colorectal carcinoma and its resection margin overexpress gastrin and receptors for gastrin (CCK(B)-R), and COX-2; 2) here, we propose that an increased plasma level of gastrin should be considered as suitable biomarker of colorectal cancer, 3) HP infection may contribute to colonic cancerogenesis by enhancing expression of gastrin and COX-2, they may account for stimulation of the tumor growth, angiogenesis and reduction in apoptosis as evidenced an increased ratio of mRNA expression for anti-apoptotic Bcl2 over proapoptotic Bax proteins and 4) HP positive patients who develop colorectal cancer should be subjected to the HP eradication; this is expected to reduce hypergastrinemia and to attenuate COX-2 expression. 11687726 2002
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE We thus hypothesized that pPXN-Y31/Y118 may be required for Bcl-2 protein stability via PXN interacting with Bcl-2 to confer 5-FU resistance in colorectal cancer. 25323586 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE The present work provides the first evidence of a UCA1-miR-204-5p-CREB1/BCL2/RAB22A regulatory network in CRC and reveals that UCA1 and CREB1 are potential new oncogenes and prognostic factors for CRC. 27046651 2016
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. 17332927 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. 12670866 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. 21455217 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE Specifically, the compound-induced mitotic arrest in CRC cells by destabilizing microtubules and activating the mitochondrial apoptotic pathway via regulation of B-cell lymphoma 2 (Bcl-2) family proteins (increasing Bcl-2 associated X (BAX) and decreasing B-cell lymphoma-extra-large (Bcl-xL)) ultimately led to caspase-mediated apoptosis. 31141929 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker disease BEFREE We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue, while MSH6 was positively associated with miR-142-5p in the normal tissue. 24895601 2014