Gene: KRAS ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE When anatomic subsite was additionally considered, the strongest association was found for KRAS mutation-negative, distal colorectal tumors (RR = 0.64; 95% CI, 0.43-0.96; P = 0.03). 22337533 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN Approximately 50% of colorectal tumors contain K-ras gene mutations, which occur as an early step in carcinogenesis. 15514939 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE K-ras-2 mutations and DNA content heterogeneity represent early events of human colorectal tumor progression. 7698570 1995
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN Recurrent KRAS codon 146 mutations in human colorectal cancer. 16969076 2006
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE The SNaPshot analysis detected KRAS c35 mutations in colorectal tumor tissue in 14 cases, but the presence of the mutation was not confirmed in cfDNA extracted from blood samples of these patients. 28365952 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. 19164213 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE KRAS mutations were retrospectively studied using polymerase chain reactions and subsequent sequencing of codons 12 and 13 (exon 2) in 110 patients with metastatic colorectal tumors. 20020061 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE The failure of EGFR inhibitors in colorectal tumors with KRAS mutations requires the development of alternative treatment strategies for this patient subgroup. 24351336 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN Dual effect of Kras(D12) knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy. 16091732 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. 20956938 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance. 15943410 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE Approximately 50% of colorectal tumors contain K-ras gene mutations, which occur as an early step in carcinogenesis. 15514939 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations. 17707462 2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN K-ras mutations and RASSF1A promoter methylation in colorectal cancer. 12032847 2002
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE Of 16 human colorectal tumors with activating mutations in KRAS, 15 displayed loss of basolateral EGFR localization. 20563247 2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE KRAS mutations are present in 40% of colorectal tumors and monitoring the mutational status together with the level of mutated DNA is of great interest. 25446878 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. 18577988 2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE Activating mutations in the KRAS gene are found in 30-40% of colorectal tumors and are associated with poor response to anti-EGFR therapies. 18802721 2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE K-Ras mutations were detected in 32.5% (41/126) of the colorectal tumors. 23183114 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE In this study, we investigated whether or not our applied DNA extraction method from stools could produce enough DNA for the molecular screening of colorectal tumors by K-ras gene mutations in stools. 12012008 2002
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group LHGDN CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. 18834226 2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE We evaluated 2121 colorectal tumors for mutations in codons 12 and 13 of the KRAS gene. 21305640 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE KRAS is mutated in about 20-25% of all human cancers and especially in pancreatic, lung and colorectal tumors. 26028667 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 GeneticVariation group BEFREE Present data clearly show that EGFR status is independent of K-Ras mutations in colorectal tumors. 18632722 2008