Source: CLINVAR ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR "APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""." 10737795 2000
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. 23845441 2013
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. 23204322 2012
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer. 24518971 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. 19794125 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. 22180495 2012
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		0.200 GeneticVariation group CLINVAR APC inhibits ERK pathway activation and cellular proliferation induced by RAS. 16478791 2006
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR APC mutations occur early during colorectal tumorigenesis. 1528264 1992
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 CausalMutation group CLINVAR Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. 22734028 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 CausalMutation group CLINVAR Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. 20978259 2010
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.410 CausalMutation group CLINVAR AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. 17699718 2007
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF as a target for cancer therapy. 21426297 2011
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.410 CausalMutation group CLINVAR BRAF mutation predicts sensitivity to MEK inhibition. 16273091 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF V600E is a determinant of sensitivity to proteasome inhibitors. 24107445 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis. 20857202 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 CausalMutation group CLINVAR BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells. 19881948 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis. 21716161 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis. 24594804 2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.490 CausalMutation group CLINVAR Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. 18725974 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.160 CausalMutation group CLINVAR Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. 18725974 2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.500 CausalMutation group CLINVAR Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival. 26623049 2015
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. 8187091 1994
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845 2009
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		0.300 GeneticVariation group CLINVAR Colorectal cancer: mutations in a signalling pathway. 16094359 2005
Entrez Id: 324
Gene Symbol: APC
APC 		0.900 GeneticVariation group CLINVAR Comprehensive molecular characterization of human colon and rectal cancer. 22810696 2012