Gene: BRAF ×
Source: CLINVAR ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Mutations of the BRAF gene in human cancer. 12068308 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD). 18186519 2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. 19001320 2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. 19794125 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. 19363522 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Clinical biomarkers in oncology: focus on colorectal cancer. 19537845 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. 20619739 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. 20413299 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery. 20350999 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy? 21129611 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis. 20857202 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF as a target for cancer therapy. 21426297 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. 21163703 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis. 21716161 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. 21343559 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. 21190184 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. 22535154 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. 22281684 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. 22180495 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR The road to resistance: EGFR mutation and cetuximab. 22310681 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. 22448344 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth. 23812671 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. 23845441 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.500 CausalMutation group CLINVAR Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer. 23325582 2013