Gene: MLH1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 GeneticVariation group LHGDN A founder MLH1 mutation in families from the districts of Modena and Reggio-Emilia in northern Italy with hereditary non-polyposis colorectal cancer associated with protein elongation and instability. 14985405 2004
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 GeneticVariation group LHGDN A single nucleotide substitution (-107C-->G) in the hMLH1 promoter found in colorectal cancer population reduces transcriptional activity. 17690979 2007
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 AlteredExpression group LHGDN Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma. 16984616 2006
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 Biomarker group BEFREE Analysis of colorectal tumors from probands included a microsatellite instability study and immunohistochemical evaluation for MLH1 and MSH2. 20305446 2010
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Assessment of MLH1 promoter methylation in relation to gene expression requires specific analysis. 17546041 2007
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. 18339680 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 GeneticVariation group LHGDN Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia. 15996210 2005
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome. 17973250 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 AlteredExpression group LHGDN Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer. 15816455 2005
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group BEFREE Cytosine methylation of the hMLH1 promoter region was found in these four colorectal tumors, whereas cytosine methylation of the hMLH1 promoter region was absent in adjacent normal tissue or in nine tumors that expressed hMLH1. 9041175 1997
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 GeneticVariation group BEFREE Defects in MSH2 and MLH1 account for most cases of hereditary non-polyposis colorectal cancer as well as for sporadic colorectal tumors. 17080293 2006
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. 19165197 2009
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers. 12203784 2002
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer. 14726676 2004
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Evidence for heritable predisposition to epigenetic silencing of MLH1. 17230510 2007
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 AlteredExpression group BEFREE Expression of the DNA mismatch repair gene hMLH1 is diminished or absent in some hyperplastic polyps, and it has been suggested that HPP1 inactivation is associated with the progression of microsatellite-unstable colorectal tumors. 12384516 2002
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 AlteredExpression group LHGDN Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer. 18497967 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 Biomarker group CTD_human Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer. 18497967 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 AlteredExpression group LHGDN Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. 18097574 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 AlteredExpression group BEFREE Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. 18097574 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 AlteredExpression group LHGDN Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age. 12627505 2003
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group LHGDN Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC. 18301449 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 GeneticVariation group LHGDN Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing. 17569143 2007
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 PosttranslationalModification group BEFREE HES1 loss correlates with the development of human right-sided colorectal tumors with epigenetic loss of MLH1. 27639802 2017
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		0.400 GeneticVariation group LHGDN High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas. 14508843 2003