Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group CTD_human Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. 25944804 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group BEFREE We used microarray analysis to associate levels of Smad4 and β-catenin mRNA in colorectal tumor samples from 250 patients. 22115830 2012
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group BEFREE Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors. 20707908 2011
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group CTD_human SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. 20565773 2010
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group BEFREE Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells. 20622003 2010
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells. 17994767 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group BEFREE We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues. 17390050 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group LHGDN Our results indicate that absence of Smad4 expression correlated significantly with liver metastases regardless of the time of their occurrence and represents a promising new biomarker to predict liver metastasis in colorectal cancer patients. 17390050 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group BEFREE Mutation or deletion of Smad4 is found in about 50% of pancreatic tumors and in about 15% of colorectal tumors. 16135802 2005
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group LHGDN SMAD4 gene alteration was found in patients, diagnosed with multiploid colorectal carcinomas. 16082587 2005
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group CTD_human SMAD4 levels and response to 5-fluorouracil in colorectal cancer. 16144935 2005
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 AlteredExpression group LHGDN Inactivation of the DPC4 gene contributes to the genesis of colorectal carcinoma through allelic loss 15063137 2004
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. 14715079 2004
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group LHGDN Two missense mutations in the C-terminal domain of Smad4, D351H (Asp351-- > His) & D537Y (Asp537-- > Tyr), from colorectal cancer cells cannot interact with either TGF-beta-induced phosphorylated Smad2 or Smad3. 14715079 2004
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group LHGDN Smad4 point mutations are prevalent in pancreatic carcinoma, they are infrequent in early stages (I-III) of colorectal cancer. 12569386 2003
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Role of Smad4 (DPC4) inactivation in human cancer. 12821112 2003
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group BEFREE These results indicate that mutations in SMAD4 play a significant role in the malignant progression of colorectal tumors. 11197776 2001
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group BEFREE DCC and Smad4 aberrations have been previously identified in pancreatic and colorectal tumors. 10698524 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 Biomarker group BEFREE We have now studied mutations in K-RAS, p53, DPC4, and TGFbetaRII in a panel of colorectal tumors with or without CIMP. 10639144 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Transcriptional control by the TGF-beta/Smad signaling system. 10775259 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients. 10479724 1999
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 GeneticVariation group BEFREE These results indicate that mutations in DPC4 (SMAD4) play a significant role in the malignant progression of colorectal tumors. 9506519 1998
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.500 CausalMutation group CLINVAR TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. 9679244 1998