Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 AlteredExpression disease BEFREE Higher circulating OPN and OPG levels have been associated with the presence of insulin resistance, atherosclerosis and coronary heart disease. 30132286 2019
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 GeneticVariation disease BEFREE Elevated circulating osteoprotegerin (OPG) level is associated with an increased risk of hospitalization for ischemic stroke and coronary artery disease. 30658955 2019
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE Osteoprotegerin and Osteopontin Serum Levels are Associated with Vascular Function and Inflammation in Coronary Artery Disease Patients. 31642412 2019
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 AlteredExpression disease BEFREE Elevated OPG level has also been associated with the degree of coronary calcification in the general population and it has been considered to be a marker of coronary atherosclerosis. 30747085 2019
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE VEGFR2 and OPG genes modify the risk of subclinical coronary atherosclerosis in patients with familial hypercholesterolemia. 30991288 2019
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease. 31049693 2019
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 AlteredExpression disease BEFREE Elevated levels of osteoprotegerin, a secreted tumor necrosis factor-related molecule, might be associated with adverse outcomes in patients with coronary artery disease. 29330256 2018
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE Prognostic significance of arterial stiffness and osteoprotegerin in patients with stable coronary artery disease. 29330911 2018
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 AlteredExpression disease BEFREE Differential expression of osteopontin, and osteoprotegerin mRNA in epicardial adipose tissue between patients with severe coronary artery disease and aortic valvular stenosis: association with HDL subclasses. 28821297 2017
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE Associations appeared stronger at younger age (P = 0.018 for cardiovascular disease), in studies that did not employ statistical adjustment (P = 0.023 for cardiovascular disease and 0.018 for coronary heart disease), and potentially in studies that measured osteoprotegerin in plasma rather than in serum (P = 0.005 for cardiovascular disease and 0.018 for coronary heart disease). 28837646 2017
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 AlteredExpression disease BEFREE The number of diseased vessels (a marker of the severity of coronary atherosclerosis) and the Gensini score (a marker of the extent of coronary atherosclerosis), as well as the OPG and TRACP-5b levels were measured in CAD patients. 28428481 2017
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE Our results suggest that a polymorphism of the TNFRSF11B gene, which encodes osteoprotegerin, is associated with the presence of coronary atherosclerosis in patients with RA. 25679449 2015
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 GeneticVariation disease BEFREE The effects of osteoprotegerin (OPG) gene polymorphism in patients with ischaemic heart disease on the morphology of coronary arteries and bone mineral density. 21678294 2011
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE Since elevated plasma levels of osteoprotegerin (OPG) represent a risk factor for death and heart failure in patients affected by diabetes mellitus and coronary artery disease, this study aimed to elucidate potential roles of OPG in the pathogenesis of atherosclerosis. 19907187 2010
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 GeneticVariation disease BEFREE Thus, the aim of this study was to investigate the relationship between OPG gene polymorphisms and aortic calcification or coronary artery disease in Koreans. 16712673 2006
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 Biomarker disease BEFREE Based on its role in inflammation and matrix degradation, we hypothesized a role for osteoprotegerin (OPG), RANK, and RANK ligand (RANKL) in coronary artery disease. 16424351 2006
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B
0.100 GeneticVariation disease BEFREE Osteoprotegerin gene polymorphisms in men with coronary artery disease. 15292302 2004