| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | SPLUNC1 is rapidly degraded in CF sputum as well as by a number of individual proteases known to be found in the sputum. | 29936069 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | We have previously demonstrated that SPLUNC1 binds to and inhibits ENaC to maintain fluid homeostasis in airway epithelia and that this process fails in CF airways. | 29295861 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Unlike SPLUNC1, the novel SPLUNC1-derived peptide SPX-101 resisted protease degradation, bound apically to HBECs, inhibited ENaC and prevented ASL dehydration following extended pre-incubation with CF sputum.Our data indicate that CF mucosal secretions drive ASL hyperabsorption and that protease-resistant peptides, <i>e.g.</i> SPX-101, can reverse this effect to rehydrate CF ASL. | 30190268 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | The S18 peptide is a naturally occurring short palate lung and nasal epithelial clone 1 (SPLUNC1)-derived ENaC antagonist that restores airway surface liquid height for up to 24 h in CF human bronchial epithelial cultures. | 28982737 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis. | 25574903 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | Here, we show that SPLUNC1 is a pH-sensitive regulator of ENaC and is unable to inhibit ENaC in the acidic CF airway environment. | 24043776 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. | 24124190 | 2013 | ||||
|
0.080 | Biomarker | disease | LHGDN | The epithelium of small airways of CF lung exhibit significantly increased SPLUNC1 staining compared to similar sized airways in non-CF lungs where staining is absent. | 17988392 | 2007 | ||||
|
0.080 | Biomarker | disease | BEFREE | The epithelium of small airways of CF lung exhibit significantly increased SPLUNC1 staining compared to similar sized airways in non-CF lungs where staining is absent. | 17988392 | 2007 |