| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.400 | GeneticVariation | disease | BEFREE | The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) is associated with lower enzymatic activity than the Val allele and is reported to be associated with aggression, depression, and suicidal behavior. | 18828035 | 2008 | ||||
|
0.400 | GeneticVariation | disease | BEFREE | The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of > or = 8. | 18578865 | 2008 | ||||
|
0.400 | Biomarker | disease | BEFREE | COMT was associated with depression following exposure to stressors (chi2=13.05, d.f.=2, p=0.0015) and SERTPR also showed a positive association (chi2=6.70, d.f.=2, p=0.035), mainly among women and among major depressives. | 16756688 | 2007 | ||||
|
0.400 | GeneticVariation | disease | BEFREE | In the 22q11.2 deletion syndrome group, baseline subthreshold psychotic symptoms interacted both with the COMT genotype and with baseline symptoms of anxiety or depression to predict 61% of the variance in severity of psychosis at follow-up evaluation. | 17403981 | 2007 | ||||
|
0.400 | GeneticVariation | disease | BEFREE | We tested for preferential transmission of COMT alleles from parent to affected offspring (n = 749) for each of the five factor-derived scales (negative symptoms, delusions, hallucinations, mania, and depression). | 16921496 | 2006 | ||||
|
0.400 | AlteredExpression | disease | BEFREE | Furthermore, the subdivision into two subpopulations, one with normal COMT activity and another with lower COMT activity, did not make it possible to assign a role to the enzyme in the severity of depression. | 3478963 | 1987 | ||||
|
0.400 | AlteredExpression | disease | BEFREE | No correlation was found between the changes in COMT activity and the psychopathological picture of depression or the severity of endogenous depressive syndrome. | 6846043 | 1983 |