HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three haplotypes were markedly associated with diabetes in Jewish Ethiopian patients: DRB1*0301 DQA1*05 DQB1*02 (OR 4.4, p < 0.001); DRB1*0404 DQA1 03 DQB1*0302 (OR 19.2, p = 0.006), and DRB1*0405 DQA1*03 DQB1*0302 (OR 87.8, p < 0.001).
|
15603874 |
2004 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 (DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent.
|
18065518 |
2008 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among patients with diabetes with DQ8, Addison's disease was strongly associated with the specific DRB1 subtype, DRB1*0404 (8 of 9 patients from 8 families, in contrast to only 109 of 408 DQ8 DM patients with diabetes without Addison's disease having DRB1*0404; P < 0.001).
|
9920103 |
1999 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We correlated T and B cell responses to insulin in subjects with increased genetic risk (HLA-DRB1*04, DQB1*0302) for diabetes with or without islet autoantibodies (Ab+ subjects and controls, respectively) and HLA-matched patients.
|
14679078 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting Bangladeshi children and adolescents <22 years of age.
|
31669629 |
2019 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Highest risk was conferred by the genotype DRB1*03-DQA1*0501-DQB1*0201/DRB1*0401-DQA1*0301-DQB1*0302 (5% absolute risk of diabetes by age 15 yr), although sensitivity was only 22.6%.
|
15292346 |
2004 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion.
|
15388265 |
2004 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between the DRB1*04 alleles and prediabetic islet autoimmunity were generally in the same direction as those with diabetes.
|
14679080 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To examine human leukocyte antigen HLA DRB1-DQB1 haplotypes within a multi-ethnic cohort and assess their association with characteristics of diabetes onset.
|
22913598 |
2013 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among HLA class II haplotypes, both HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) ("at-risk class II haplotypes") were positively associated with diabetes (OR = 6.7 and 6.0, respectively) (p(c) < 0.003).
|
10819246 |
2000 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A negative association with diabetes was observed for the DQB1*0602, 0503, 0301, and 0601 alleles, as well as the DRB1*0403 subtype.
|
16629714 |
2006 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
High frequency of the HLA-DRB1*0405-(Dw15)-DQw8 haplotype in Spaniards and its relationship to diabetes susceptibility.
|
1774197 |
1991 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four hundred Spanish pediatric patients with recent-onset diabetes (mean age 8.9 ± 3.9 years) were analyzed for IAA, GADA, IA2A and ZnT8A pancreatic-autoantibodies and HLA-DRB1 alleles.
|
31365591 |
2019 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 13% of the GADab(+) patients with diabetes had genotypes comprising the DRB1*1501-DQB1*0602 or *1502-*0601 and were characterized by old age at onset of diabetes, high BMI, resistance to the insulin-deficient state, low titer of GADab, and low frequency of other organ-specific autoantibodies.
|
12032105 |
2002 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the frequency of HLA class II (DQA1, DQB1 and DRB1) associated to susceptibility or protection toT1DM in a Brazilian racially admixtured with diabetes.
|
20073143 |
2009 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents <22 years of age.
|
30710658 |
2019 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.
|
7729610 |
1995 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the DRB1*0401-DQB1*0302/(DR13)-DQB1*0603 genotype was disease predisposing, implying that DQB*0603-mediated protection from diabetes is not always dominant.
|
12889996 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*1503-DQ6 haplotype was associated with protection from diabetes in the Jamaican population.
|
11841488 |
2002 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fewer children with the diabetes-associated human leukocyte antigen DRB1*03-DQB1*02 genotype tested positive for enterovirus RNA (P=.02).
|
12721936 |
2003 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our analyses indicate that the counterbalancing act between susceptible DRB1 and protective DQB1, and vice versa, that has already been observed in Chinese and Japanese, is the major factor responsible for the low incidence of diabetes in Koreans.
|
9831135 |
1998 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we identified markers that define DRB1*1501 DQB1*0602 haplotypes conferring reduced protection from diabetes in a Swedish 13th IHW data set.
|
17445204 |
2007 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess the frequency of HLA class II (DPA1, DPB1, DQA1, DQB1 and DRB1) associated to susceptibility or protection toT1DM in a Bengali population of India with diabetes.
|
23441825 |
2013 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Japanese type 1 susceptible HLA haplotypes, DRB1*0901-DQB1*0303 was more frequent in type 1A diabetes than fulminant diabetes (7/18 vs. 0/18, P=0.004), whereas the frequency of DRB1*0405-DQB1*0401 was similar (type 1A 4/18 vs. fulminant 6/18).
|
14581155 |
2003 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genotypes DRB1* 04DQB1 *0302/DRB1*04DQB1*0302 and DRB1 *03DQB1*02/DRB1*04DQB1* 0302 were associated with an early onset of diabetes, while homozygosity for DRB1*03DQB1*02 was characterized by later onset.
|
10227564 |
1999 |