|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR-gamma2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated.
|
11793024 |
2001 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results of this study suggested that the PGC-1 gene might be implicated in the pathogenesis of Type II diabetes.
|
12107756 |
2002 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population.
|
12606537 |
2003 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM.
|
12832613 |
2003 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
The nuclear hormone receptor coactivator PGC-1 (peroxisome proliferator-activated (PPAR)-gamma coactivator-1) has been implicated in the onset of type 2 diabetes.
|
15107844 |
2004 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, the PGC-1alpha gene locus influences carbohydrate metabolism and contributes to type 2 diabetes in the population studied.
|
15111510 |
2004 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The prevalent Gly482Ser variant in PGC-1 was shown to be associated with type 2 diabetes in some but not all studies.
|
15146371 |
2004 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
PGC-1alpha and PGC-1beta mRNA levels and the mitochondrial genes they regulate are decreased in muscle of people with prediabetes and T2DM.
|
15545992 |
2004 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we suggest that the AA genotype of the Gly482Ser polymorphism of the PGC-1 gene should be considered as a risk factor for the development of type 2 diabetes in Caucasians.
|
15581067 |
2004 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the Pro12Pro genotype of the PPAR-gamma2 gene and the 482Ser allele of the PGC-1alpha gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
CTD_human |
We conclude that the Pro12Pro genotype of the PPAR-gamma2 gene and the 482Ser allele of the PGC-1alpha gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension frequently found in subjects with type 2 diabetes.
|
15599700 |
2004 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggested linkage between the chromosomal region of PGC-1alpha and fasting serum insulin levels, and associates a Gly482Ser polymorphism of the gene with type 2 diabetes and hypertension.
|
15649578 |
2005 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.
|
15782399 |
2005 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here.
|
15824463 |
2004 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that PPARGC1A is likely to contribute to the risk of diabetes in offspring of patients with type 2 diabetes.
|
15912394 |
2005 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no strong association between SNPs or haplotypes of PPARGC1A and type 2 diabetes.
|
15937669 |
2005 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate whether genetic variations in human PPARGC1 gene are associated with metabolic syndrome-related phenotypes and T2D among obese subjects.
|
16122961 |
2006 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The A allele of Thr394Thr (G --> A) polymorphism of the PGC-1 gene is associated with Type 2 diabetes in Asian Indian subjects and the XA genotype confers 1.6 times higher risk for Type 2 diabetes compared with the GG genotype in this population.
|
16241916 |
2005 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We can conclude that reduced PGC-1alpha expression described in Type 2 diabetes may be partly explained by muscle inactivity.
|
16326070 |
2006 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies have suggested that the common PPARGC1A polymorphism Gly482Ser may be associated with risk of type 2 diabetes, with conflicting results.
|
16435105 |
2006 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The variant allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A or PGC1alpha), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 diabetes.
|
16474966 |
2006 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The observation that PPARGC1A and the PPARs were upregulated in the adipose tissue of type 2 diabetic patients, along with the finding that adipose tissue from some patients with type 2 diabetes can express UCP1 mRNA, suggests that in these patients white adipose tissue may move towards a brown adipose tissue phenotype.
|
16538490 |
2006 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
This review focuses on the role of PGC-1alpha in glucose metabolism and considers how PGC-1alpha links cellular glucose metabolism, insulin sensitivity and mitochondrial function, and why defects in PGC-1alpha expression and regulation may contribute to the pathophysiology of type 2 diabetes in humans.
|
16752166 |
2006 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives.
|
16896940 |
2006 |