| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.960 | Biomarker | disease | BEFREE | Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. | 29301787 | 2018 | ||||
|
0.960 | AlteredExpression | disease | BEFREE | Newer drug targets such as protein kinase B (Akt/PKB), AMP-activated protein kinase (AMPK), sirtuin (SIRT), and others are novel approaches that act via different mechanisms and possibly treating T2DM of distinct variations and aetiologies. | 29696964 | 2018 | ||||
|
0.960 | GeneticVariation | disease | BEFREE | In this study, we aimed to test whether polymorphisms in the PIK3CA (catalytic subunit of PI3K), AKT1, AKT2, and FRAP1 (mTOR) genes were associated with the risk of type 2 diabetes mellitus (T2DM) among Chinese population. | 28477532 | 2017 | ||||
|
0.960 | Biomarker | disease | BEFREE | AKT2 is closely linked to Type II diabetes and the implications of various types of mutations are discussed. | 24039187 | 2013 | ||||
|
0.960 | Biomarker | disease | BEFREE | In order to determine whether the Akt2 gene plays a role in the pathogenesis of type 2 diabetes characterized by insulin resistance, and to further identify if variations in this gene have a relationship with type 2 diabetes, we sequenced the entire coding region and splice junctions of Akt2 and made a further case-control study to explore the association between single-nucleotide polymorphisms (SNPs) in this gene and type 2 diabetes in the Chinese Han population. | 21518566 | 2011 | ||||
|
0.960 | GeneticVariation | disease | BEFREE | Furthermore, genetic variation in and around the AKT2 locus is unlikely to contribute significantly to the risk of type 2 diabetes or related intermediate metabolic traits in U.K. populations. | 17327441 | 2007 |