Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.300 Biomarker group CTD_human HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. 6770269 1980
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.300 Biomarker group CTD_human HLA antigens and adverse drug reactions to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. 3157529 1985
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.300 Biomarker group CTD_human Toxicity due to remission inducing drugs in rheumatoid arthritis. Association with HLA-B35 and Cw4 antigens. 3084782 1986
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.300 Biomarker group CTD_human HLA-A,-B, and -DR antigens in relation to gold and D-penicillamine toxicity in Greek patients with RA. 3133153 1986
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.300 Biomarker group CTD_human Longterm followup of treatment with D-penicillamine for rheumatoid arthritis: effectivity and toxicity in relation to HLA antigens. 3437418 1987
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.300 Biomarker group CTD_human Grand mal seizures after 2-chloroprocaine epidural anesthesia in a patient with plasma cholinesterase deficiency. 3111302 1987
Entrez Id: 4254
Gene Symbol: KITLG
KITLG 		0.300 Therapeutic group CTD_human Potential use of human stem cell factor as adjunctive therapy for human immunodeficiency virus-related cytopenias. 1720698 1991
Entrez Id: 1440
Gene Symbol: CSF3
CSF3 		0.300 Therapeutic group CTD_human Phase I and pharmacologic study of paclitaxel and cisplatin with granulocyte colony-stimulating factor: neuromuscular toxicity is dose-limiting. 7692001 1993
Entrez Id: 3562
Gene Symbol: IL3
IL3 		0.300 Therapeutic group CTD_human Further studies to ameliorate toxicity of carboplatin. 8202718 1994
Entrez Id: 1437
Gene Symbol: CSF2
CSF2 		0.300 Therapeutic group CTD_human FIVB plus GM-CSF in metastatic colorectal cancer. 7960606 1994
Entrez Id: 5972
Gene Symbol: REN
REN 		0.300 Biomarker group CTD_human Prediction of renal impairment in elderly patients with congestive heart failure treated with captopril. 8723173 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.200 Biomarker group CTD_mouse Methamphetamine-induced serotonin neurotoxicity is attenuated in p53-knockout mice. 9369336 1997
Entrez Id: 1544
Gene Symbol: CYP1A2
CYP1A2 		0.300 Biomarker group CTD_human Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice. 10445756 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker group CTD_human Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice. 10698006 2000
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9 		0.300 Biomarker group CTD_human Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin. 11740344 2001
Entrez Id: 9
Gene Symbol: NAT1
NAT1 		0.300 Biomarker group CTD_human A genetic polymorphism in NAT1 is associated with an increased risk of various cancers and drug toxicities, but epidemiological investigations are severely compromised by a poor understanding of the relationship between NAT1 genotype and phenotype. 11505221 2001
Entrez Id: 7295
Gene Symbol: TXN
TXN 		0.200 Therapeutic group CTD_mouse Transgene expression of thioredoxin (TRX/ADF) protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hematotoxicity. 11462148 2001
Entrez Id: 10769
Gene Symbol: PLK2
PLK2 		0.300 Biomarker group CTD_human Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. 12897130 2003
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A 		0.300 Biomarker group CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
Entrez Id: 134
Gene Symbol: ADORA1
ADORA1 		0.300 Biomarker group CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
Entrez Id: 3484
Gene Symbol: IGFBP1
IGFBP1 		0.300 Biomarker group CTD_human Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. 15805072 2005
Entrez Id: 4548
Gene Symbol: MTR
MTR 		0.300 Biomarker group CTD_human MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. 15753437 2005
Entrez Id: 10568
Gene Symbol: SLC34A2
SLC34A2 		0.300 Biomarker group CTD_human Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. 15805072 2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.300 Biomarker group CTD_human Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate. 16166815 2005
Entrez Id: 6578
Gene Symbol: SLCO2A1
SLCO2A1 		0.300 Biomarker group CTD_human Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. 15805072 2005