Gene: SIRT1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Therapeutic disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease CTD_human Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. 23834033 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Therapeutic disease CTD_human Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. 23834033 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Therapeutic disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2013
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease BEFREE Therefore, we investigated whether the beneficial effects of exendin-4 treatment on fatty liver are mediated via Sirt1 in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models. 22363635 2012
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease BEFREE These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease BEFREE The degradation leads to inhibition of SIRT1 function, which contributes to development of hepatic steatosis. 21540183 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Therapeutic disease CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease BEFREE We therefore propose that the DBC1-SIRT1 interaction may serve as a new target for therapies aimed at nonalcoholic liver steatosis. 20071779 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 AlteredExpression disease BEFREE SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. 20033348 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.600 Biomarker disease MGD