Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.360 | Biomarker | disease | BEFREE | Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in <i>Gynostemma pentaphylla</i> (Thunb.) Makino treated mice. | 30555521 | 2018 | ||||
|
0.360 | Biomarker | disease | BEFREE | Dysregulation of circRNA_0046366/miR-34a/PPARα signaling may be a novel epigenetic mechanism underlying hepatocellular steatosis. circRNA_0046366 serves as a potential target for the treatment of hepatic steatosis. | 29391755 | 2018 | ||||
|
0.360 | Biomarker | disease | BEFREE | Activating AMPK<i>α</i> negatively regulates Egr1 to inhibit inflammatory cytokines in high glucose. miR-34a inhibition increases phosphorylated AMPK<i>α</i> through mediating SIRT1 to suppress the development of fatty liver. | 29681936 | 2018 | ||||
|
0.360 | Biomarker | disease | BEFREE | These findings indicate a circRNA_0046367/miR-34a/PPAR<i>α</i> regulatory system underlying hepatic steatosis. | 29018509 | 2017 | ||||
|
0.360 | Biomarker | disease | BEFREE | Here we show that hepatocyte nuclear factor 4α (HNF4α), a liver-enriched nuclear hormone receptor, is markedly inhibited, whereas miR-34a is highly induced in patients with non-alcoholic steatohepatitis, diabetic mice and mice fed a high-fat diet. miR-34a is essential for HNF4α expression and regulates triglyceride accumulation in human and murine hepatocytes. miR-34a inhibits very low-density lipoprotein secretion and promotes liver steatosis and hypolipidemia in an HNF4α-dependent manner. | 26100857 | 2015 | ||||
|
0.360 | Biomarker | disease | CTD_human | Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. | 23834033 | 2013 | ||||
|
0.360 | Biomarker | disease | BEFREE | p53 and its transcriptional target miRNA34a have been implicated in the pathogenesis of fatty liver. | 23211317 | 2013 |