Gene: JPH2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 57158
Gene Symbol: JPH2
JPH2 		0.050 GeneticVariation disease BEFREE Whereas pressure overload accrued atrial dysfunction and heart failure with 40% mortality, additional junctophilin-2 knockdown greatly exacerbated atrial dysfunction with 100% mortality. 31217359 2019
Entrez Id: 57158
Gene Symbol: JPH2
JPH2 		0.050 Biomarker disease BEFREE RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. 30867288 2019
Entrez Id: 57158
Gene Symbol: JPH2
JPH2 		0.050 GeneticVariation disease BEFREE Heterozygous junctophilin-2 (JPH2) p.(Thr161Lys) is a monogenic cause for HCM with heart failure. 30235249 2018
Entrez Id: 57158
Gene Symbol: JPH2
JPH2 		0.050 Biomarker disease BEFREE After cardiac stress, JP2 is cleaved by the calcium ion-dependent protease calpain, which disrupts the E-C coupling ultrastructural machinery and drives heart failure progression. 30409805 2018
Entrez Id: 57158
Gene Symbol: JPH2
JPH2 		0.050 Biomarker disease BEFREE Acute loss of SPEG in mouse hearts causes JPH2 dephosphorylation and transverse-tubule loss associated with downstream Ca<sup>2+</sup> mishandling leading to HF. 27729468 2017