Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | disease | BEFREE | Nox2 activation requires membrane translocation of the p47(phox) subunit and is linked to heart failure. | 23553616 | 2013 | ||||
|
0.370 | Biomarker | disease | BEFREE | In LV tissues, protein expressions of inflammatory (tumor-necrosis factor-α/nuclear-factor-κB/interleukin-1ß/matrix-metalloprotianse-9), oxidative stress (NOX-1/NOX-2/oxidized protein), apoptotic (mitochondrial-Bax/cleaved-caspase-3/cleaved-PARP), fibrotic (transforming-growth factor-ß/Smad3), DNA/mitochondrial-damage (γ-H2AX/cytosolic-cytochrome-C) and heart failure (brain natriuretic peptide (BNP) levels displayed an opposite pattern to LVEF among the three groups (all p < 0.0001). | 30404073 | 2019 | ||||
|
0.370 | Biomarker | disease | BEFREE | These results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 complex underlies attenuation of hyperglycemia-induced heart failure by TRPC6. | 28790356 | 2017 | ||||
|
0.370 | Biomarker | disease | CTD_human | MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. | 20304815 | 2010 | ||||
|
0.370 | Biomarker | disease | BEFREE | Overall, our findings suggest that Nox2 is an important source of ROS in the diaphragm of patients with HF and increases in levels of antioxidant enzymes are not sufficient to maintain normal redox homeostasis. | 28119629 | 2016 | ||||
|
0.370 | Biomarker | disease | BEFREE | Echocardiography revealed that ALDH-2(-/-)/gp91(phox-/-) mice were protected from ACA-overload-induced HF after 5 weeks of 2% EtOH-diet, demonstrating that NOX2-derived O2(•-) contributes to the development of ACM. | 27624556 | 2016 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | ED in HF rats is associated with decreased NO bioavailability in erectile tissue due to eNOS/nNOS dowregulation and NOX2 upregulation, as well as hypercontractility of the penis. | 29095897 | 2017 | ||||
|
0.370 | Biomarker | disease | BEFREE | Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice. | 31228552 | 2019 |