Gene: IL1B ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.400 GeneticVariation disease BEFREE Compared with those who took no IL-1 blockage, patients taking IL-1 blockage experienced a decreased risk of overall MACE (RR 0.88, 95% CI 0.82-0.94), unstable angina (RR 0.80, 95% CI 0.66-0.98), and breakthrough or recurrence of heart failure (RR 0.44, 95% CI 0.22-0.87). 31415103 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.400 Biomarker disease BEFREE The multivariable logistic regression showed that IL-1β [relative ratio (RR) = 1.08, 95% CI: 1.02-1.15, <i>P</i> = 0.010], IL-6 (RR = 1.03, 95% CI: 1.01-1.06, <i>P</i> = 0.016), PTX-3 (RR = 1.31, 95% CI: 1.11-1.55, <i>P</i> = 0.001), and ANGPTL-4 (RR = 1.05, 95% CI: 1.02-1.07, <i>P</i> < 0.001) were independently associated with HF, while IL-6 (RR = 1.03, 95% CI: 1.01-1.04, <i>P</i> = 0.019), PTX-3 (RR = 1.23, 95% CI: 1.06-1.43, <i>P</i> = 0.007), and ANGPTL-4 (RR = 1.03, 95% CI: 1.01-1.06, <i>P</i> = 0.005) were independently associated with the HF subtype. 31105751 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.400 Biomarker disease BEFREE Most advanced are clinical studies with IL-1 antagonists showing improved β-cell function and glycemia and prevention of cardiovascular diseases and heart failure. 31127805 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.400 AlteredExpression disease BEFREE Expression levels of IL-1ß, IL-6, TNF-alpha, and BAX mRNA were significantly associated with the degree of CHF. 30968846 2019