However, loss of <i>Akap1</i> exacerbated LVH and cardiomyocyte hypertrophy induced by pressure overload and accelerated the progression toward HF in TAC mice, and these changes were not observed upon prevention of AKAP121 degradation in seven <i>in absentia</i> homolog 2 (<i>Siah2</i>) knockout mice (<i>Siah2</i><sup>-/-</sup>).