Gene: PROC ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 AlteredExpression disease BEFREE Emicizumab-mediated haemostatic function in patients with haemophilia A is down-regulated by activated protein C through inactivation of activated factor V. 30125997 2018
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 Biomarker disease BEFREE Finally, new approaches to develop procoagulant aptamers to control bleeding associated with hemophilia and other coagulopathies involve targeting activated protein C and tissue plasminogen activator. 30015643 2018
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 Biomarker disease BEFREE However, when coinherited with haemophilia, fV<sub>Leiden</sub> reduces bleeding severity, suggesting that inhibition of APC may be a useful strategy for treatment of haemophilia. 29884816 2018
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 Biomarker disease BEFREE Targeting APC with a serpin is remarkably effective and may be safe for long-term prophylactic use in the treatment of hemophilia. 28632502 2017
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 Biomarker disease BEFREE Selective inhibition of APC might therefore be effective for the treatment of hemophilia. 27789479 2017
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 Biomarker disease BEFREE Dampening APC's inhibition of factor V (FV) and factor VIII (FVIII) may be a future strategy in developing next-generation therapeutic targets for haemophilia treatment. 28750471 2017
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 AlteredExpression disease BEFREE Our present findings suggest that FVIIa displacement of anticoagulant protein C from EPCR that results in down-regulation of activated protein C generation and not the direct effect of EPCR-FVIIa on FX activation is the mechanism by which FVIIa interaction with EPCR contributes to the hemostatic effect of rFVIIa in hemophilia therapy. 28932824 2017
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 Biomarker disease BEFREE Patients with haemophilia appear to generate normal concentrations of APC during basal conditions. 19175419 2009
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.090 GeneticVariation disease BEFREE A nonsense mutation in the activated protein C cleavage site at amino acid 336 was discovered in a patient with severe hemophilia. 3137981 1988