A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICBrs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations.
A sequencing-based typing method and genotyping of MICA and MICB in a well-characterized group of Cuban individuals with dengue hemorrhagic fever (DHF), dengue fever (DF), or asymptomatic dengue infection (ADI) was performed.