|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese.
|
21408128 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported.
|
25041342 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The genome-wide association study (GWAS) variant (rs9277535; 550A/G) in the 3'UTR of the HLA-DPB1 gene that associated most significantly with chronic hepatitis B and outcomes to HBV infection in Asians had a marginal effect on HBV recovery in our European- and African-American samples (odds ratio [OR] = 0.39, P = 0.01, combined ethnic groups).
|
22496224 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to evaluate the relation of OBI to HLA-DP single nucleotide polymorphisms (SNPs) encoding antigen-binding sites for the immune response to HBV infection.
|
29061159 |
2017 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All the minor alleles of these HLA-DP candidate SNPs were correlated with lower likelihoods of nonresponse to HB vaccine.
|
25389088 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
|
19349983 |
2009 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In sum, we showed, for the first time, that the HLA-DP/DQ clusters contribute independently to HBV infection, and the 3'-UTR region of HLA-DPB1 represents an important functional region involved in HBV infection.
|
26197724 |
2015 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population.
|
28267888 |
2017 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus.
|
19349983 |
2009 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.
|
23449268 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We performed a case-control study nested in a well-characterized cohort of booster recipients to assess whether genetic variants of HLA-DPB1 are also associated with response to hepatitis B (HB) vaccination.
|
23739870 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
When frequencies of DRB1-DQB1 haplotypes and DPB1 alleles were compared between low immune responders and HBV patients, significant associations were identified for three DRB1-DQB1 haplotypes, and no association was identified for any of the DPB1 alleles.
|
29534301 |
2018 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Response to hepatitis B vaccination is co-determined by HLA-DPA1 and -DPB1.
|
31515149 |
2019 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.
|
24520320 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results further confirmed the strong influence of HLA-DP gene variants on risk of spontaneous HBV clearance from persistent HBV infection.
|
22543033 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Researches reported single nucleotide polymorphism (SNP) of HLA-DP associated with HBV infection and autoimmune diseases such as SLE.
|
29476350 |
2018 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive).
|
23825586 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings indicated that variants in antigen-binding regions of HLA-DP and HLA-DQ contribute to the risk of persistent HBV infection.
|
21750111 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine the effect of HLA-DP polymorphisms on the generation of HBV mutations and their interactions on the outcomes of HBV infection. rs3077, rs3135021, rs9277535, and rs2281388 were genotyped in 1,342 healthy controls, 327 HBV clearance subjects, and 2,736 HBV-positive subjects, including 1,108 hepatocellular carcinoma (HCC) patients, using quantitative PCR.
|
24006435 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4-1.9; p = 1).
|
22448225 |
2012 |