An open-label, single-center experience with 10 patients using a multistep informed consent reported successful transplantation of HCV-seropositive viremic (HCV-V) kidneys into HCV-seronegative recipients.<sup>2</sup> Subsequently, a case was reported in which an HCV-V liver was transplanted into a HCV-seronegative recipient.<sup>3</sup> In collaboration with OPTN/UNOS, we identified cases in which HCV-V deceased donor livers were transplanted into HCV-seronegative recipients.