Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1815
Gene Symbol: DRD4
DRD4 		0.060 GeneticVariation disease BEFREE DRD4 exon III VNTR polymorphism-susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach. 10673776 2000
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		0.400 GeneticVariation disease BEFREE Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. 12657887 2003
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.010 GeneticVariation disease BEFREE ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence. 18424454 2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.380 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) and oxidative stress may play a role in patients with heroin dependence. 28063398 2017
Entrez Id: 406947
Gene Symbol: MIR155
MIR155 		0.010 Biomarker disease BEFREE Hsa-miR-155-5p may be a promising regulatory point for the treatment of heroin addiction. 31692007 2020
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2 		0.010 GeneticVariation disease BEFREE A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction. 29953524 2018
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		0.400 GeneticVariation disease BEFREE A recent study suggested that a second nearby variant within OPRM1, rs3778150, is robustly associated with heroin dependence and fully explained a smaller observed association with rs1799971. 28273335 2017
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1 		0.230 Biomarker disease RGD A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats. 24725195 2015
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.600 GeneticVariation disease BEFREE According to the allele, genotype and haplotype frequency analysis, we observed an association between HD and several DRD2/ANKK1 polymorphisms (rs1800497, rs1800498, rs1079597 and rs4648319); this was most notable in the late-onset HD subgroup. 28854834 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.380 GeneticVariation disease BEFREE Additionally, we found that rs6265, rs11030104 and rs10767664 in BDNF were associated with a decreased risk of heroin addiction (p < 0.05). 27647760 2016
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.300 Biomarker disease CTD_human Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. 15717844 2005
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Biomarker disease CTD_human Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. 15717844 2005
Entrez Id: 56729
Gene Symbol: RETN
RETN 		0.300 Biomarker disease CTD_human Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. 15717844 2005
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.310 Biomarker disease CTD_human Adrenocorticotropic hormone and cortisol plasma levels directly correlate with childhood neglect and depression measures in addicted patients. 18201294 2008
Entrez Id: 116444
Gene Symbol: GRIN3B
GRIN3B 		0.010 GeneticVariation disease BEFREE After Bonferroni correction, rs2240158 of GRIN3B was still found to be associated with heroin addiction. 27542340 2016
Entrez Id: 2047
Gene Symbol: EPHB1
EPHB1 		0.010 GeneticVariation disease BEFREE After logistic regression analyses, no statistically significant effect of NET variants in the development of HD was found. 20818294 2011
Entrez Id: 6530
Gene Symbol: SLC6A2
SLC6A2 		0.010 GeneticVariation disease BEFREE After logistic regression analyses, no statistically significant effect of NET variants in the development of HD was found. 20818294 2011
Entrez Id: 2004
Gene Symbol: ELK3
ELK3 		0.010 GeneticVariation disease BEFREE After logistic regression analyses, no statistically significant effect of NET variants in the development of HD was found. 20818294 2011
Entrez Id: 12
Gene Symbol: SERPINA3
SERPINA3 		0.010 GeneticVariation disease BEFREE Also, in Hispanics only we found the haplotype GACT consisting of four variants (-184G>A, -179A>G, 833A>C and 1005C>T) to be significantly associated with heroin addiction (p=0.0014, experiment-wise p=0.0168), whereas another haplotype, AACT, consisting of the same variants, was associated with a protective effect from heroin addiction (p=0.0039, experiment-wise p=0.0468). 18359160 2008
Entrez Id: 2668
Gene Symbol: GDNF
GDNF 		0.010 GeneticVariation disease BEFREE An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD. 24022000 2013
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.030 GeneticVariation disease BEFREE An increased risk of HD was significantly associated with H alleles of PDYN VNTR (χ<sup>2</sup> = 10.824, p = 0.001, OR = 1.419, 95% CI = 1.151-1.748). 30138645 2018
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1 		0.400 GeneticVariation disease BEFREE Analysis of a combined effect of OPRM1 and OPRD1 showed that rs510769 and rs2236861 increase the risk of heroin addiction (P = 0.0005). 18518925 2008
Entrez Id: 4985
Gene Symbol: OPRD1
OPRD1 		0.050 GeneticVariation disease BEFREE Analysis of a combined effect of OPRM1 and OPRD1 showed that rs510769 and rs2236861 increase the risk of heroin addiction (P = 0.0005). 18518925 2008
Entrez Id: 9024
Gene Symbol: BRSK2
BRSK2 		0.010 GeneticVariation disease BEFREE Analysis using the diagnostic criteria of heroin dependence yielded suggestive evidence for association between variants in the genes CCDC42 (coiled coil domain 42; p = 2.8x10-7) and BRSK2 (BR serine/threonine 2; p = 4.110-6). 27936112 2016
Entrez Id: 4684
Gene Symbol: NCAM1
NCAM1 		0.010 GeneticVariation disease BEFREE ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. 23303482 2013