×
Entrez Id:
1815
Gene Symbol:
DRD4
DRD4
0.060
GeneticVariation
disease
BEFREE
DRD4 exon III VNTR polymorphism-susceptibility factor for heroin dependence ? Results of a case-control and a family-based association approach.
10673776
2000
×
Entrez Id:
4988
Gene Symbol:
OPRM1
OPRM1
0.400
GeneticVariation
disease
BEFREE
Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations.
12657887
2003
×
Entrez Id:
5243
Gene Symbol:
ABCB1
ABCB1
0.010
GeneticVariation
disease
BEFREE
ABCB1 (MDR1 ) genetic variants are associated with methadone doses required for effective treatment of heroin dependence .
18424454
2008
×
Entrez Id:
627
Gene Symbol:
BDNF
BDNF
0.380
Biomarker
disease
BEFREE
Brain-derived neurotrophic factor (BDNF ) and oxidative stress may play a role in patients with heroin dependence .
28063398
2017
×
Entrez Id:
406947
Gene Symbol:
MIR155
MIR155
0.010
Biomarker
disease
BEFREE
Hsa-miR-155 -5p may be a promising regulatory point for the treatment of heroin addiction .
31692007
2020
×
Entrez Id:
1395
Gene Symbol:
CRHR2
CRHR2
0.010
GeneticVariation
disease
BEFREE
A non-coding CRHR2 SNP rs255105 , a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction .
29953524
2018
×
Entrez Id:
4988
Gene Symbol:
OPRM1
OPRM1
0.400
GeneticVariation
disease
BEFREE
A recent study suggested that a second nearby variant within OPRM1 , rs3778150 , is robustly associated with heroin dependence and fully explained a smaller observed association with rs1799971 .
28273335
2017
×
Entrez Id:
4986
Gene Symbol:
OPRK1
OPRK1
0.230
Biomarker
disease
RGD
A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats.
24725195
2015
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.600
GeneticVariation
disease
BEFREE
According to the allele, genotype and haplotype frequency analysis, we observed an association between HD and several DRD2 /ANKK1 polymorphisms (rs1800497 , rs1800498 , rs1079597 and rs4648319 ); this was most notable in the late-onset HD subgroup.
28854834
2019
×
Entrez Id:
627
Gene Symbol:
BDNF
BDNF
0.380
GeneticVariation
disease
BEFREE
Additionally, we found that rs6265 , rs11030104 and rs10767664 in BDNF were associated with a decreased risk of heroin addiction (p < 0.05).
27647760
2016
×
Entrez Id:
9370
Gene Symbol:
ADIPOQ
ADIPOQ
0.300
Biomarker
disease
CTD_human
Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment.
15717844
2005
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.300
Biomarker
disease
CTD_human
Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment.
15717844
2005
×
Entrez Id:
56729
Gene Symbol:
RETN
RETN
0.300
Biomarker
disease
CTD_human
Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment.
15717844
2005
×
Entrez Id:
5443
Gene Symbol:
POMC
POMC
0.310
Biomarker
disease
CTD_human
Adrenocorticotropic hormone and cortisol plasma levels directly correlate with childhood neglect and depression measures in addicted patients.
18201294
2008
×
Entrez Id:
116444
Gene Symbol:
GRIN3B
GRIN3B
0.010
GeneticVariation
disease
BEFREE
After Bonferroni correction, rs2240158 of GRIN3B was still found to be associated with heroin addiction .
27542340
2016
×
Entrez Id:
2047
Gene Symbol:
EPHB1
EPHB1
0.010
GeneticVariation
disease
BEFREE
After logistic regression analyses, no statistically significant effect of NET variants in the development of HD was found.
20818294
2011
×
Entrez Id:
6530
Gene Symbol:
SLC6A2
SLC6A2
0.010
GeneticVariation
disease
BEFREE
After logistic regression analyses, no statistically significant effect of NET variants in the development of HD was found.
20818294
2011
×
Entrez Id:
2004
Gene Symbol:
ELK3
ELK3
0.010
GeneticVariation
disease
BEFREE
After logistic regression analyses, no statistically significant effect of NET variants in the development of HD was found.
20818294
2011
SERPINA3
0.010
GeneticVariation
disease
BEFREE
Also, in Hispanics only we found the haplotype GACT consisting of four variants (-184G>A, -179A>G, 833A>C and 1005C>T) to be significantly associated with heroin addiction (p=0.0014, experiment-wise p=0.0168), whereas another haplotype, AACT , consisting of the same variants, was associated with a protective effect from heroin addiction (p=0.0039, experiment-wise p=0.0468).
18359160
2008
×
Entrez Id:
2668
Gene Symbol:
GDNF
GDNF
0.010
GeneticVariation
disease
BEFREE
An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD .
24022000
2013
×
Entrez Id:
5173
Gene Symbol:
PDYN
PDYN
0.030
GeneticVariation
disease
BEFREE
An increased risk of HD was significantly associated with H alleles of PDYN VNTR (χ<sup>2</sup> = 10.824, p = 0.001, OR = 1.419, 95% CI = 1.151-1.748).
30138645
2018
×
Entrez Id:
4988
Gene Symbol:
OPRM1
OPRM1
0.400
GeneticVariation
disease
BEFREE
Analysis of a combined effect of OPRM1 and OPRD1 showed that rs510769 and rs2236861 increase the risk of heroin addiction (P = 0.0005).
18518925
2008
×
Entrez Id:
4985
Gene Symbol:
OPRD1
OPRD1
0.050
GeneticVariation
disease
BEFREE
Analysis of a combined effect of OPRM1 and OPRD1 showed that rs510769 and rs2236861 increase the risk of heroin addiction (P = 0.0005).
18518925
2008
×
Entrez Id:
9024
Gene Symbol:
BRSK2
BRSK2
0.010
GeneticVariation
disease
BEFREE
Analysis using the diagnostic criteria of heroin dependence yielded suggestive evidence for association between variants in the genes CCDC42 (coiled coil domain 42; p = 2.8x10-7) and BRSK2 (BR serine/threonine 2; p = 4.110-6).
27936112
2016
×
Entrez Id:
4684
Gene Symbol:
NCAM1
NCAM1
0.010
GeneticVariation
disease
BEFREE
ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence : importance of considering drug exposure.
23303482
2013