Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Targeting the IL-4/IL-13 signaling pathway sensitizes Hodgkin lymphoma cells to chemotherapeutic drugs. | 23553437 | 2013 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Genes which were more highly expressed in EBV blasts were substantially and significantly enriched for a set of interferon-stimulated genes which on further in silico analyses were found to be repressed by IL-4 in other cell contexts and to be up-regulated in micro-dissected malignant cells from Hodgkin's lymphoma biopsies when compared to their normal germinal center cell counterparts. | 23724103 | 2013 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma. | 20876453 | 2011 | ||||
|
0.090 | Biomarker | disease | BEFREE | Expansion of Vdelta1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins. | 16973957 | 2007 | ||||
|
0.090 | Biomarker | disease | BEFREE | We have previously reported that exposure to CD40 ligand and IL-4 could induce LMP-1 in an in vitro EBV-infected Hodgkin lymphoma-derived cell line, which expressed only EBNA-1. | 16332968 | 2006 | ||||
|
0.090 | AlteredExpression | disease | LHGDN | In conclusion, there is increased production of IL4 by PHA-activated PB lymphocytes in HL. | 14654080 | 2004 | ||||
|
0.090 | Biomarker | disease | BEFREE | IgE isotype switching induced by anti-CD40 mAb with cytokines other than IL-4 was first demonstrated, whereas none of the non-Hodgkin's lymphomas except mantle cell lymphoma and lymphoplasmacytic lymphoma showed IgE isotype switching in response to any of the stimuli. | 10812244 | 2000 | ||||
|
0.090 | Biomarker | disease | BEFREE | T-cell clones were also raised from purified CD4+ lymphocytes of one HD lymph node and one reactive lymph node and tested for IL2, IL4, IL5 and IFN-gamma secretion in culture supernatants by immunoassays. | 9407718 | 1998 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Other cytokine expression was rare except two cases of HD with high amounts of IL-4 mRNA. | 1951632 | 1991 |