Moreover, CSF markers associated with shunt-dependent hydrocephalus included increased levels of <sub>CSF</sub>TP on days 5 (AUC = 0.72)/11 (AUC = 0.97)/14 (AUC = 0.98), <sub>CSF</sub>IL-6 on day 14 (AUC = 0.81), and <sub>CSF</sub>RBC on day 15 (AUC = 0.83).
A significant correlation was found between a) Higher stage of TBM and various cytokines (except for serum IL-6 and CSF IFN-γ); b) High CSF TNF-α, IL-4 and IL-1β with severity of hydrocephalus; c) High CSF IL1β and IFN-γ with presence of exudates on MRI; d) Serum and CSF levels of all cytokines with poor outcome as determined by death or as defined by S and E ADL (Schwab and England activities of daily living) score or by GOS (Glasgow outcome scale) (except for interferon gamma); and e) Serum and CSF IL-4 and IL1β with presence of infarcts on MRI brain.
Moreover, we observed that the levels of IL-6 and IL-8 in the group with idiopathic active hydrocephalus were significantly higher compared to patients with arrested hydrocephalus and hydrocephalus with brain atrophy.</i>.