Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.360 | GeneticVariation | group | BEFREE | Indices of pulmonary hypertension were measured in rats treated with the epidermal growth factor receptor inhibitor gefitinib. | 31264901 | 2020 | ||||
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0.360 | Biomarker | group | BEFREE | Conclusions- Taken together, our findings implicate an unexpected role of the TGF-β-EGFR pathway in hypertension with current translational perspectives. | 30354220 | 2018 | ||||
|
0.360 | AlteredExpression | group | BEFREE | Logistic regression analysis suggested that increased EGFR levels exhibit 3‑fold higher risk of CAD [odds ratio (OR) 3.51, 95% confidence interval [CI] 1.96‑6.28, P≤0.001], upon adjustment for hypertension, diabetes and smoking. | 29328373 | 2018 | ||||
|
0.360 | GeneticVariation | group | BEFREE | The randomisation was done by the Chinese Thoracic Oncology Group with a web-based allocation system applying the Pocock and Simon minimisation method; groups were stratified by EGFR gene mutation status, treatment line (first line or second line), brain metastases only versus both intracranial and extracranial metastases, and presence or absence of symptoms of intracranial hypertension. | 28734822 | 2017 | ||||
|
0.360 | AlteredExpression | group | BEFREE | Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension. | 26928584 | 2016 | ||||
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0.360 | Biomarker | group | BEFREE | For example, both bevacizumab and vascular endothelial growth factor receptor (VEGFR) kinase inhibitors cause hypertension; both epidermal growth factor receptor (EGFR) antibodies and kinase inhibitors cause rash; and these toxicities correlate with response. | 24867380 | 2014 | ||||
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0.360 | Biomarker | group | RGD | Enhanced expression of EGF receptor in a model of salt-sensitive hypertension. | 15827348 | 2005 | ||||
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0.360 | Biomarker | group | HPO |